Talk:LAE-32

Chemical Nomenclature

Common names

LAE-32, LAE

Substitutive name

d-Lysergic acid ethylamide

Systematic name

N-ethyl-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide

Class Membership

Psychoactive class

Psychedelic

Chemical class

Lysergamide

Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.

⇣ Sublingual
Dosage
Threshold	0.5-1.5 mg
Duration

DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Summary sheet: LAE-32

Lysergic acid ethylamide (also known as LAE-32, LAE, and d-ethyllysergamide) is a semisynthetic psychedelic substance of the lysergamide class that is structurally similar to LSD. LAE-32 is one of the least known and least researched psychedelic substances. The pharmacology of LAE-32 is complex^{[citation needed]}, but it acts primarily by binding to serotonin receptors in the brain, much like LSD and other serotonergic psychedelics.^{[citation needed]}

The CIA and Project MKULTRA Findings

LAE-32 was experimented with by the CIA as part of Project MKULTRA. It was reported to create a condition similar to that of schizophrenia in mentally healthy individuals, characterized by indifference and depersonalization. While it was reported that, when used on schizophrenics, it created a condition that allowed the patients to become indifferent to their hallucinations and cease hallucinatory excitation.

Chemistry

LAE-32, or d-lysergic acid ethylamide, is a semisynthetic substance of the lysergamide family. LAE-32's chemical structure consists of a bicyclic hexahydroindole ring fused to a bicyclic quinoline group (lysergic acid). At carbon 8 of the quinoline an N, generally N-ethyl carboxamide is bound, LAE-32 is additionally substituted at carbon 6 with a methyl group.

Pharmacology

LAE-32 most likely acts by binding to serotonin receptors in the brain. It may, like LSD, bind to dopamine receptors as well.

Subjective effects

The subjective effects of LAE-32 are reportedly mainly sedating and depersonalizing, creating a state of indifference in users.

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), a research literature based on anecdotal reports and the personal experiences of PsychonautWiki contributors. As a result, they should be regarded with a healthy degree of skepticism. It is worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become much more likely with higher doses and may include addiction, serious injury, or death.

Physical effects

- Pupil dilation
- Sedation - This effect is mild compared to traditional sedatives such as barbiturates and benzodiazepines.

Cognitive effects

- Personal bias suppression
- Motivation suppression - LAE-32 is unique among psychedelics for its ability to suppress willpower.
- Personality regression

Dangerous interactions

Although many psychoactive substances are reasonably safe to use on their own, they can suddenly become dangerous or even life-threatening when combined with other substances. The following list includes some known dangerous combinations (although it is not guaranteed to include all of them). Independent research (e.g. Google, DuckDuckGo) should always be conducted to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

Cannabis - Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics. Extreme caution is advised when using this combination as it can significantly increase the chances of a negative psychological reaction like anxiety, confusion and psychosis. Users are advised to start off with only a fraction of their usual cannabis dose and take long breaks between hits to avoid over intake.
Amphetamines & Cocaine - Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences.
Tramadol - Tramadol is well known to lower seizure threshold and psychedelics also cause occasional seizures.

Legal status

LAE-32 is not explicitly illegal in any nation, but it is possibly illegal to possess in the United States for purposes of consumption due to the Federal Analog Act.

External links

References

Talk:LAE-32

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