Risperidone

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Summary sheet: Risperidone

Risperidone
Chemical Nomenclature
Common names	Risperdal
Substitutive name	Risperidone
Systematic name	3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one
Class Membership
Psychoactive class	Antipsychotic
Chemical class	Benzisoxazole
Routes of Administration
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. ⇣ Oral Dosage Threshold 0.25 mg Light 0.5 - 1 mg Common 1 - 3 mg Strong 3 - 6 mg Heavy 6 mg + Duration Total 12 - 20 hours Onset 20 - 60 minutes Peak 2 - 8 hours Offset 2 - 4 hours After effects 12 - 24 hours DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Interactions

Risperidone (also known as Risperdal) is an atypical antipsychotic medication of the benzisoxazole chemical class. Risperidone is prescribed for bipolar disorder, autism, and psychotic disorders, such as in schizophrenia. It is sometimes used as a sedative to reduce the effects of psychedelics like LSD and to induce sleepiness. Benzodiazepines are also used for this purpose.

Chemistry

This chemistry section is incomplete. You can help by adding to it.

Pharmacology

This pharmacology section is incomplete. You can help by adding to it.

Risperidone has a complex pharmacology, but its main mechanism of action is as a D2 dopaminergic receptor antagonist. This means that it blocks dopamine from binding to the receptor, meanwhile not activating it. It also blocks most of the serotonin receptors, being an inverse agonist at the 5-HT_2A, 5-HT_2B, and 5-HT_2C serotonin receptors. Risperidone has the strongest affinity to the 5-HT_2A receptor. On top of that, it acts as an irreversible antagonist at the 5-HT₇ serotonin receptor. Its hypnotic effects come from the blockade of dopamine D2 receptors.

Subjective effects

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects

• • Appetite enhancement
  • Sedation - Risperidone produces strong sedation and can result in an overwhelmingly lethargic state. At higher levels, risperidone can cause users to suddenly feel as if they are extremely sleep deprived and have not slept for days, forcing them to sit down and generally feel as if they are constantly on the verge of passing out instead of engaging in physical activities. This sense of sleep deprivation increases proportional to dosage and eventually becomes powerful enough to force a person into complete unconsciousness.
  • Dizziness
  • Decreased libido
  • Increased heart rate
  • Motor control loss
  • Nausea suppression

Cognitive effects

• The general head space of risperidone is often described as one of sleepiness, emptiness, apathy, stupor and catatonia. The specific cognitive effects can be broken down into several components which progressively intensify proportional to dosage. These are described below and generally include:
  • Amnesia
  • Anxiety suppression
  • Analysis suppression
  • Apathy
  • Creativity suppression
  • Language suppression
  • Emotion suppression
  • Focus suppression
  • Sleepiness
  • Thought deceleration
  • Motivation suppression
  • Appetite enhancement

Experience reports

There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:

• Erowid Experience Vaults: Risperidone

Toxicity and harm potential

This toxicity and harm potential section is a stub. As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it. Note: Always conduct independent research and use harm reduction practices if using this substance.

Legal status

• Australia: Risperidone is available only through prescription.
• Germany: Risperidone is a prescription medicine, according to Anlage 1 AMVV.
• Switzerland: Risperidone is listed as a "Abgabekategorie B" pharmaceutical, which requires a prescription.
• United Kingdom: Risperidone is available only through prescription.
• United States: Risperidone is available only through prescription.

See also

• Responsible use
• Antipsychotic
• Quetiapine
• Depressant

External links

• Risperidone (Wikipedia)
• Risperidone (Erowid Vault)
• Risperidone (TiHKAL / Isomer Design)

References

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