Talk:Etazene

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Etazene
DMT.svg
Chemical Nomenclature
Common names DMT, Dimethyltryptamine, Dmitri
Substitutive name N,N-Dimethyltryptamine
Systematic name 2-(1H-Indol-3-yl)-N,N-dimethylethanamine
Class Membership
Psychoactive class Psychedelic
Chemical class Tryptamine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



Oral
Dosage
Bioavailability x% - y%[1]
Threshold x - mg
Light x - y mg
Common x - y mg
Strong x - y mg
Heavy x mg +
Duration
Total x - y hours
Onset x - y minutes
Come up x - y minutes
Peak x - y hours
Offset x - y hours
After effects x - y hours


Sublingual
Dosage
Bioavailability x% - y%
Threshold x - mg
Light x - y mg
Common x - y mg
Strong x - y mg
Heavy x mg +
Duration
Total a - b hours
Onset a - b minutes
Come up a - b minutes
Peak a - b hours
Offset a - b hours
After effects a - b hours







DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.


Etazene is a synthetic opioid analgesic sold as a research chemical.

History and culture

Very little is known about etaznenes origin, it first came to the public eye in 2020, when it was first siezed by law enforcement. People speculate it is a etazene like Research chemical, with similar effects but a much lower LD50 etazene is an analgesic drug, first reported in 2020, that has been shown to have approximately one thousand to one thousand five hundred times the potency of morphine in animal models, but only sixty to seventy times the potency in humans.

Because it is characterized by a strong dependency potential and a tendency to produce profound respiratory depression, it is not used in humans. It is, however, useful in animal models for addiction studies, particularly those requiring the animals to drink or ingest the agent, because it is not as bitter as opiate salts like morphine sulfate.

Pharmacology

Opioids exert their effects by binding to and activating the μ-opioid receptor. This occurs because opioids structurally mimic endogenous endorphins which are naturally found within the body and also work upon the μ-opioid receptor set. The way in which opioids structurally mimic these natural endorphins results in their euphoria, pain relief and anxiolytic effects. This is because endorphins are responsible for reducing pain, causing sleepiness, and feelings of pleasure. They can be released in response to pain, strenuous exercise, orgasm, or general excitement.

Chemistry

Etazene is a synthetic opioid in the benzimidazole family. The structures of opioids share many similarities. Whereas opioids like codeine, hydrocodone, oxycodone, and hydromorphone are synthesized by simple modifications of morphine, etazene and its relatives are synthesized using the benzimidazole chemical structure.

Subjective effects

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), a research literature based on anecdotal reports and the personal experiences of PsychonautWiki contributors. As a result, they should be regarded with a healthy degree of skepticism. It is worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become much more likely with higher doses and may include addiction, serious injury, or death.

Physical effects
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Experience reports

There are currently 0 experience reports which describe the effects of this substance in our experience index.


Toxicity and harm potential

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This toxicity and harm potential section is a stub.

As such, it may contain incomplete or even dangerously wrong information. You can help by expanding or correcting it.
We also recommend that you conduct independent research and use harm reduction practices when using this substance.

The short-term non-chronic use of opioids is not associated with any physical or neurological toxicity.[citation needed]

Long term effects

The long-term use of opioids causes hormonal imbalance in both men and women.

This negative change in endocrine function in males can lead to: reduced libido, erectile dysfunction, fatigue, depression, reduced facial and body hair, decreased muscle mass, and weight gain.

It is strongly recommended that one use harm reduction practices when using this class of substances.

Dependence and tolerance potential

As with other opioids, the chronic use of e tazenecan be considered highly addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal symptoms may occur if a person suddenly stops their usage.

Tolerance to many of the effects of Etazene develops with prolonged and repeated use. The rate at which this occurs develops at different rates for different effects, with tolerance to the constipation-inducing effects developing particularly slowly for instance. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). Etazene presents cross-tolerance with all other opioids, meaning that after the consumption of Etazene all opioids will have a reduced effect.

External links

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