Diarylethylamine

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The general structure for a diarylethylamine

Diarylethylamines are psychoactive drugs, which typically have dissociative effects.

Pharmacology

NMDAR binding affinities for five target 1,2-diphenylethylamines and reference compounds

Compound	IC50 ± SEM (nM)	Ki ± SEM (nM)
PCP	91 ± 1.3	57.9 ± 0.8
Ketamine	508.5 ± 30.1	323.9 ± 19.2
Memantine	594.2 ± 41.3	378.4 ± 26.3
(+)-MK-801	4.1 ± 1.6	2.5 ± 1.0
DPH (Diphenidine)	28.6 ± 3.5	18.2 ± 2.2
2-MXP (Methoxphenidine)	56.5 ± 5.8	36.0 ± 3.7
3-MXP	30.3 ± 2.6	19.3 ± 1.7
4-MXP	723.8 ± 69.9	461.0 ± 44.5
2-Cl-DPH	14.6 ± 2.1	9.3 ± 1.3
NMDAR binding affinites determined using [3H]-(+)-MK-801 in rat forebrain.

Examples

• Diphenidine
• Ephenidine
• Methoxphenidine (MXP)

See also

• Responsible use
• Dissociative
• Arylcyclohexylamine