Diarylethylamine

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The general structure for a diarylethylamine

Diarylethylamines are psychoactive drugs, which typically have dissociative effects.

Pharmacology

NMDAR binding affinities for five target 1,2-diphenylethylamines and reference compounds[1]
Compound IC50 ± SEM (nM) Ki ± SEM (nM)
PCP[2] 91 ± 1.3 57.9 ± 0.8
Ketamine 508.5 ± 30.1 323.9 ± 19.2
Memantine 594.2 ± 41.3 378.4 ± 26.3
(+)-MK-801 4.1 ± 1.6 2.5 ± 1.0
DPH (Diphenidine) 28.6 ± 3.5 18.2 ± 2.2
2-MXP (Methoxphenidine) 56.5 ± 5.8 36.0 ± 3.7
3-MXP 30.3 ± 2.6 19.3 ± 1.7
4-MXP 723.8 ± 69.9 461.0 ± 44.5
2-Cl-DPH 14.6 ± 2.1 9.3 ± 1.3
NMDAR binding affinites determined using [3H]-(+)-MK-801 in rat forebrain.[3]

Examples

See also

References

  1. http://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0157021.t001
  2. http://gradworks.umi.com/36/90/3690548.html
  3. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0157021