Talk:Olanzapine
| Summary sheet: Olanzapine |
| Olanzapine | |||||||||||||||||||||||||||||||||
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| Chemical Nomenclature | |||||||||||||||||||||||||||||||||
| Common names | Olanzapine, Zyprexa | ||||||||||||||||||||||||||||||||
| Systematic name | 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine | ||||||||||||||||||||||||||||||||
| Class Membership | |||||||||||||||||||||||||||||||||
| Psychoactive class | Antipsychotic | ||||||||||||||||||||||||||||||||
| Chemical class | Thienobenzodiazepine | ||||||||||||||||||||||||||||||||
| Routes of Administration | |||||||||||||||||||||||||||||||||
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Olanzapine, first branded as Zyprexa, is a widely-used antipsychotic substance of the thienobenzodiazepine chemical class. It produces sedating and neuroleptic effects when administered. Olanzapine can be given by mouth and can also be injected into a muscle. Olanzapine might be useful as a trip aborter, especially for stimulants, as it blocks the action of dopamine. [citation needed]
Chemistry
Olanzapine is a thienobenzodiazepine. It includes a piperazine moiety at R4.
Olanzapine is classified as a thienobenzodiazepine derivative. Its chemical structure consists of a fused tricyclic system incorporating a thiophene ring and a diazepine ring. Specifically, olanzapine features a piperazine substituent at the R4 position of the diazepine moiety. This piperazine ring is believed to contribute to its affinity for various neurotransmitter receptors, particularly serotonergic and dopaminergic sites. The compound has a molecular formula of C17H20N4OS, with a molecular weight of 312.44 g/mol. Its IUPAC name is 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine. Syrex1013 (talk) 00:26, 27 June 2025 (UTC)
Pharmacology
Olanzapine is known to cause weight gain and induce diabetes mellitus type 2 more frequently than other antipsychotics. However, it is less likely to produce tardive dyskinesia or an extrapyramidal reaction. It appears to be an effective treatment for schizophrenia.[2]
Subjective effects
Physical effects 
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- Hunger - This often happens over a course of treatment and not with one use.
- Sedation - This effect is more often uncomfortably tiring than relaxing.
- Salivation
- Muscle relaxation
- Motor control loss
- Dizziness
- Perception of bodily heaviness
- Headaches
- Extrapyramidal symptoms
Cognitive effects 
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- Anxiety suppression - This is mediated by olanzapine's antidopaminergic, antiadrenergic, and antiserotonergic action rather than GABA-related activity.
- Emotionality suppression - Olanzapine dulls and suppresses emotions.
- Focus suppression or enhancement - This often depends on the mental state of the individual.
- Decreased libido
- Sleepiness
- Cognitive euphoria - This effect is extremely rare. Olanzapine is often a dulling, "boring" pharmaceutical.
- Cognitive dysphoria - This often includes a sense of boredom or depression accompanied by uncomfortable sedation.
Experience reports
There are currently 0 experience reports which describe the effects of this substance in our experience index.
Additional experience reports can be found here:
External links
References
- ↑ https://doi.org/10.2165%2F00003088-200746050-00001
- ↑ Leucht, S., Cipriani, A., Spineli, L., Mavridis, D., Örey, D., Richter, F., ... & Kissling, W. (2013). Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis. The Lancet, 382(9896), 951-962.