Talk:Mescaline

Forbiden Fruit Archives

Reference link http://entheogen.netfirms.com/articles/articles/Narcotic_Cacti.html is down. ExistingEntity (talk) 17:57, 15 April 2017 (CEST)

5HT-2A

I'm a little bit undecided with the statement: It binds to and activates the serotonin 5-HT2A receptor with a high affinity, due to the fact that it has no recorded affinity to the 2A receptor to my knowledge.

Josi (?) wrote about it in her blog: However, drugs like mescaline and MDMA are both capable of inducing psychedelic experiences on par with that of psilocin and LSD, but show no affinity to the 5HT-2A receptor. Also, the study Psychedelics and the Human Receptorome shows no affinity at all of Mescaline on the 5HT-2A receptor.

--Apx (talk) 12:42, 27 April 2016 (UTC)

@Kenan I would just like to note that the Ray study "Psychedelics and the Human Receptorome" has been discredited and rejected by the psychedelics research community, as well as the lab that conducted the assays themselves (the Psychoactive Drug Screening Program (PDSP), which I applied for a job at a year or two back. I know that the head of the program himself, Bryan Roth, has remarked that he did not trust the technician running those assays on top of the fact that I point-blanked asked David Nichols (who is also Professor Emeritus at the Roth Lab) at PS17 this year what he thought of it (largely due to the anomalous mescaline affinities, as well as some weird looking ones on other compounds) and he told me it was total scientifically unrigorous crap xD Also, I believe the assay may have simply failed for this one due to the exponentially larger amount of material that mescaline requires to display activity compared to a bunch of other psychedelics being tested, which are much better suited for testing in cell culture dishes. Also IIRC the psychedelic phenethylamines have significant 5-HT2C activity that tryptamines don't really display, but the significance of this is not really known. I will do more reading on the matter when I get more time. Clarity (talk) 19:46, 2 May 2017 (CEST)

@Clarity Acknowledged. As discussed, I'd love to see a retraction, but I guess nobody really cares..