User:ExistingEntity

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Gifts
4 of 8
giftgiftgiftgift
Account information
Drug of choice
Hallucinogens and Opioids
Other information
TV
Adventure Time, Breaking Bad, Rick and Morty
Video games
Roguelikes and Strategy Games
Snacks
Pizza, Cough Medication, Fruits
Drinks
Tea, Water, Mandarin Juice, Dairy
Statistics
Edits 221
Personal information
Birthday
January 1st
Occupation
Existing
Places I have lived
Europe
About me
Not dead. Gratitude to all for caring. Might re-emerge sometime in a different form.
Board
10 of 12
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posted 536 days ago
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I would also like to know if you are OK.

posted 553 days ago
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How's it going? Are you OK?

posted 579 days ago
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Yes. If there is no doi don't worry about converting the PMID (you can't). Just put it at the end of the cite :)

posted 579 days ago
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BTW I just wanted to thank you for all the recent edits!!! They've been extremely helpful. Thank you!

posted 579 days ago
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(on MDMA).

As for your serotonergic psychedelics point, well, it's a good point. I was actually thinking about it the other day. I will discuss the matter with the team and get back to you :)

posted 590 days ago
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Just wanted to say I've been loving your edits so far dude. Congrats on being made Scholar!

posted 590 days ago
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ExistingEntity,

herewith you are being promoted to being a scholar. This grants you special rights, including editing restricted articles like Heroin and Fentanyl. The decision is based on a review of your contributions, which we have found to be of high quality. We don't usually promote any contributor in such a short timeframe - and we hope that this trust meets responsibility.

Thank you for being a contributor. Together, we can save many. Everyday.

-- Kenan

posted 592 days ago
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"Under normal conditions, THC appears to passively diffuse from fat back into blood, thus explaining its long elimination half-life. However it is possible that under conditions of enhanced fat metabolism (lipolysis), THC might be released from fat at much higher concentrations than normal."

"We have also received recent anecdotal forensic reports of high THC levels in the blood of ex-cannabis users who have lost significant body weight immediately prior to test sampling. Stress and food deprivation (FD) are reliable promoters of lipolysis, and this can be largely ascribed to activation of the sympathetic nervous system (Meisner and Carter, 1977; Palou et al., 1981; Nonogaki, 2000). Activation of the sympathetic nervous system increases the release of hormones such as adrenaline and adrenocorticotrophic hormone (ACTH), which in turn interact with adipocyte membrane-bound receptors such as β-adrenoceptors and melanocortin receptors (MC) that stimulate hormone-sensitive lipases (HSL) to hydrolyse triglycerides into free fatty acids (FFA) and glycerol (Meisner and Carter, 1977; Langin, 2006)."

"Collectively the data obtained in the present study demonstrate that lipolysis significantly enhances the release of THC from fat tissue resulting in increased levels in the blood. The lipolytic agent ACTH enhanced the release of THC from adipocytes previously treated in vitro with THC. This effect correlated with ACTH-induced lipolysis. Similarly, ACTH enhanced the release of THC from ex vivo adipocytes of rats that were repeatedly pretreated with systemic injections of THC. Complementary in vivo experiments showed that systemic ACTH or 24 h of FD both increased the blood concentrations of THC and its metabolite THC-COOH in rats pretreated in vivo with THC."


^^ From the source I found, if you can find a better one feel free to change it! And thank you for taking the time to check these things out, it's a pretty small group of people making edits and yours are really worthwhile, coherent, and useful (:

P.S. - never wish me opioids, I'm a recovering heroin addict (: I appreciate the sentiment though

posted 593 days ago
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above the physical/chemical classes I meant. From the most abstract to the most specific, is the idea :)