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Summary sheet: Aripiprazole


Aripiprazole (branded as Abilify, Aristada among others) is an atypical antipsychotic approved for the treatment of schizophrenia, psychosis, bipolar disorder, and along with an antidepressant to treat major depressive disorder.

History and culture

Aripiprazole, developed by Otsuka Pharmaceutical and marketed as Abilify among others, was first approved in Japan in 2002 and subsequently in the United States. It was a novel development in the field of atypical antipsychotics, primarily intended for schizophrenia and bipolar disorder treatment. Over time, its use expanded to include treatment of major depressive disorder and irritability in autism spectrum disorders.


Aripiprazole is a synthetic substance of the quinolinone class and is structurally distinct from other atypical antipsychotics. Its molecular formula is C_{23}H_{27}Cl_{2}N_{3}O_{2}, and it has a unique mechanism of action as a dopamine-serotonin system stabilizer.


Aripiprazole's primary mechanism involves acting as a partial agonist at dopamine D2 and D3 receptors and serotonin 5-HT1A receptors, while also serving as an antagonist at serotonin 5-HT2A receptors. This dual action contributes to its efficacy in treating both the positive and negative symptoms of schizophrenia. It also exhibits moderate affinity for histamine, adrenergic, and muscarinic receptors, contributing to some of its side effects.

Subjective effects

This subjective effects section is a stub.

As such, it is still in progress and may contain incomplete or wrong information.

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Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠. {{effects/base


Physical effects

Cognitive effects

Auditory effects

Visual effects

Experience reports

There are a limited number of experience reports for Aripiprazole given its medical usage, but some can be found in the experience index and on external platforms like Erowid.

Toxicity and harm potential


This toxicity and harm potential section is a stub.

As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it.
Note: Always conduct independent research and use harm reduction practices if using this substance.

Although generally safe at therapeutic doses, Aripiprazole overdose can lead to severe symptoms like seizures, vomiting, and agitation. Long-term use may increase the risk of metabolic syndrome.

Lethal dosage

The lethal dosage of Aripiprazole is not well-established, but it is considered to have a high therapeutic index.

Tolerance and addiction potential

Aripiprazole has a low potential for abuse and addiction. Tolerance development is minimal.

Dangerous interactions

Aripiprazole should not be combined with other substances that depress the central nervous system, such as alcohol, benzodiazepines, or opioids.

Legal status


This legality section is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

Aripiprazole is a prescription medication in many countries. Its legal status varies, but it is generally regulated and available only with a doctor's prescription.

See also

External links


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The 2016 NICE guidance for treating psychosis and schizophrenia in children and young people recommended aripiprazole as a second line treatment after risperidone for people between 15 and 17 who are having an acute exacerbation or recurrence of psychosis or schizophrenia.[1] A 2014 NICE review of the depot formulation of the drug found that it might have a role in treatment as an alternative to other depot formulations of second generation antipsychotics for people who have trouble taking medication as directed or who prefer it.[2]