User:Oskykins/NBOMe harm reduction

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Many members of the NBOMe series have been linked with numerous overdoses and fatalities.[1][2][3]

It is strongly discouraged to take higher doses of these substances or to insufflate (snort) them. Please see this section for more details.

Citations

[4][5][6]

25xNBOMe

25B-NBOMe

25B-NBOMe is a relatively new substance, and little is known about its pharmacological risks or its interaction with other substances. The lethal dosage has not yet been determined. One case has been reported on where 25B-NBOMe was identified as the cause of death for a 17-year-old boy.[7]

It is advised that due to 25B-NBOMe's extreme potency it should not be insufflated as this method of administration is potentially fatal at heavy dosages.[8]

25B-NBOMe has been used in clinical trials with an evaluation dose for safety consideration to humans of only 1 microgram; Such a dose is 300× lower than the dose expected to be hallucinogenic to humans and it is expected that recreational use would greatly exceed doses determined to be safe to humans.[9]

25I-NBOMe

25I-NBOMe is a relatively new substance, and little is known about its pharmacological risks or its interaction with other substances. The LD50 has not yet been determined although it is potentially fatal at heavy dosages.[4]

As of February 2016, 25I-NBOMe has reportedly led to ______ overdose deaths in the United States.[10][11][12] Due to 25I-NBOMe's extreme potency and fatality, it is strongly discouraged to insufflated (snort) 25I-NBOMe as this method of administration appears to have led to several deaths in the past year.[4]

25C-NBOMe

25C-NBOMe is a relatively new substance, and little is known about its pharmacological risks or its interaction with other substances. The LD50 has not yet been determined although it is potentially fatal at heavy dosages.[13] 25C-NBOMe overdoses have also been linked to multi-organ failure.[14][15]

It is advised that due to 25C-NBOMe's extreme potency it should not be snorted as this method of administration has been attributed to several near fatal overdoses due to improper dosing.[16]

25D-NBOMe

25D-NBOMe is a very new substance, and very little is known about its pharmacological risks or its interaction with other substances. The LD50 has not yet been determined.[13] Due to 25D-NBOMe's extreme potency, it should not be snorted as this method of administration appears to have led to several deaths from other NBOMe compounds in the past year.[17]

25N-NBOMe

The toxicity and long-term health effects of recreational 25N-NBOMe use have not been studied in any scientific context and the exact toxic dosage is unknown. This is because 25N-NBOMe is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried 25N-NBOMe suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

Users should be very careful and consider that ingesting 2mg+ of NBOMe series chemicals have proven fatal in some cases. Although there are no reported deaths caused by 25N-NBOMe at this time, it is a rare research chemical with very little history of human usage and is therefore potentially fatal at heavy dosages.

References

  1. 25I-NBOMe (2C-I-NBOMe) Fatalities / Deaths by Erowid | https://www.erowid.org/chemicals/2ci_nbome/2ci_nbome_death.shtml
  2. 25C-NBOMe (2C-C-NBOMe) Fatalities / Deaths by Erowid | https://www.erowid.org/chemicals/2cc_nbome/2cc_nbome_death.shtml
  3. Other or Unknown NBOMe Compound Fatalities / Deaths by Erowid | https://www.erowid.org/chemicals/nbome/nbome_death.shtml
  4. 4.0 4.1 4.2 25I-NBOMe (2C-I-NBOMe) Fatalities / Deaths by Erowid | https://www.erowid.org/chemicals/2ci_nbome/2ci_nbome_death.shtml
  5. 25C-NBOMe (2C-C-NBOMe) Fatalities / Deaths by Erowid | https://www.erowid.org/chemicals/2cc_nbome/2cc_nbome_death.shtml
  6. Other or Unknown NBOMe Compound Fatalities / Deaths by Erowid | https://www.erowid.org/chemicals/nbome/nbome_death.shtml
  7. Designer Drug Identified As Cause Of Plano Teen’s Death | http://dfw.cbslocal.com/2015/02/19/designer-drug-identified-as-cause-of-plano-teens-death/
  8. http://www.erowid.org/chemicals/nbome/nbome_death.shtml
  9. Preclinical Safety Assessment of the 5-HT2A Receptor Agonist PET Radioligand [11C]Cimbi-36 | https://bitnest.netfirms.com/external.php?id=%257DbxUgX%255DCY%2504%2505wzx%2519%2505VYL%2502RI%257E%2560d
  10. New drug N-bomb hits the street, terrifying parents, troubling cops | http://www.nydailynews.com/news/national/new-synthetic-hallucinogen-n-bomb-killing-users-cops-article-1.1336327
  11. Breaking Bad: Digital Drug Sales, Analog Drug Deaths. Craig Malisow, Houston Press, March 13, 2013 | http://www.houstonpress.com/2013-03-14/news/motion-research-charles-carlton/
  12. 21-year-old dies after one drop of new synthetic drug at Voodoo Fest. Naomi Martin, NOLA, November 1, 2012 | http://www.nola.com/crime/index.ssf/2012/11/21-year-old_dies_after_one_dro.html#incart_m-rpt-2/
  13. 13.0 13.1 "Fatalities / Deaths". Erowid. April 26 2013. Retrieved 7 May 2013. | http://www.erowid.org/chemicals/2ci_nbome/2ci_nbome_death.shtml
  14. Fatal intoxication with the new designer drug 25C-NBOMe | https://www.ncbi.nlm.nih.gov/pubmed/26324189
  15. Near fatal intoxication with the novel psychoactive substance 25C-NBOMe | https://www.ncbi.nlm.nih.gov/pubmed/24770890
  16. Near fatal intoxication with the novel psychoactive substance 25C-NBOMe | https://www.ncbi.nlm.nih.gov/pubmed/24770890
  17. http://www.erowid.org/chemicals/2ci_nbome/2ci_nbome.shtml/