Trihexyphenidyl

Deliriant use is associated with highly uncomfortable and/or dangerous experiences.

Deliriants are highly unpredictable and may result in erratic behaviors, self-injury, hospitalization, or death. It should be noted that most individuals do not choose to repeat the experience due to its unpleasant nature.

Please use harm reduction practices if using this substance (e.g. starting with a low dose and always having a trip sitter). Refer to this section for more details.

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Trihexyphenidyl (THP,  benzhexol, trihex, Artane, and others) is an anticholinergic substance of the antimuscarinic class used to treat stiffness, tremors, spasms, and poor muscle control. In high doses, it has been reported to act as a deliriant.

Trihexyphenidyl has been used for the symptomatic treatment of Parkinson's disease as approved by the FDA in the United States since 2003. It is also used for the treatment of drug-induced movement disorders such as essential tremors and akathisia, commonly caused by antipsychotics.

History and culture

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Neurologist and author Dr. Oliver Sacks reported using the drug recreationally in the 1960s, he recalled taking "a large dose" knowing full well the drug was intended for people with Parkinson's.

During the 1970s, THP (trade name Parkan) was the most popular recreational prescription drug in Hungary. In 2008, a news report mentioned that trihexyphenidyl was seen to be used for recreational purposes among Iraqi soldiers and police, stating that the drugs were taken to relieve combat stress reaction. While that was the case for some, others used it as a substitute or more intense version of LSD. This was especially prevalent in the 1960s, according to a report in "The New Yorker". Similarly to those in Iraqi forces, some of the appeal was that the individual may retain partial control while under the influence.

Chemistry

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Pharmacology

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Subjective effects

This subjective effects section is a stub. As such, it is still in progress and may contain incomplete or wrong information. You can help by expanding or correcting it.

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects

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Visual effects

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  Enhancements

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  Distortions

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  Geometry

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  Hallucinatory states

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  • Hallucinatory states1

Cognitive effects

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Auditory effects

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Multi-sensory effects

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Transpersonal effects

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  • Transpersonal effect1
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Experience reports

There are currently 0 experience reports describing the effects of this substance in our experience index. You can also submit your own experience report using the same link.

Additional experience reports can be found here:

• Erowid Experience Vaults: Trihexyphenidyl Reports

Toxicity and harm potential

This toxicity and harm potential section is a stub. As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it. Note: Always conduct independent research and use harm reduction practices if using this substance.

It is strongly recommended that one use harm reduction practices when using this substance.

Dangerous interactions

This dangerous interactions section is a stub. As such, it may contain incomplete or invalid information. You can help by expanding upon or correcting it.

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

Legal status

This legality section is a stub. As such, it may contain incomplete or wrong information. You can help by expanding it.

See also

• Responsible use

External links

• Trihexyphenidyl (Wikipedia)

Literature

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