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1200px-Thebaine skeletal.svg.png
Chemical Nomenclature
Common names Thebaine, Opium
Substitutive name Paramorphine
Systematic name 6,7,8,14-Tetradehydro-4,5α-epoxy-3,6-dimethoxy-17-methylmorphinan
Class Membership
Psychoactive class Stimulant / Opioid
Chemical class Morphian
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.

Threshold 5 - 12.5 mg
Light 12.5 - 25 mg
Common 25 - 50 mg
Strong 50 - 100 mg
Heavy 100 mg +
Total 4 - 6 hours
Onset 30 - 60 minutes
Come up 20 - 60 minutes
Peak 1 - 2 hours
Offset 3 - 5 hours
After effects 12 hours

DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.


History and culture

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This History and culture section is a stub.

As a result, it may contain incomplete or wrong information. You can help by expanding it.


Thebaine (paramorphine), also known as codeine methyl enol ether, is an opiate alkaloid naturally occurring in opium poppies.


thebaine is chemically similar to both morphine and codeine, but has stimulatory rather than depressant effects. At high doses, it causes convulsions similar to strychnine poisoning. The synthetic enantiomer (+)-thebaine does show analgesic effects apparently mediated through opioid receptors, unlike the inactive natural enantiomer (−)-thebaine.[3] While thebaine is not used therapeutically, it is the main alkaloid extracted from Papaver bracteatum (Iranian opium / Persian poppy) and can be converted industrially into a variety of compounds, including hydrocodone, Hydromorphone, Oxycodone, Oxymorphone, Nalbuphine, Naloxone, naltrexone, Buprenorphine and Etorphine. Butorphanol can also be derived from thebaine.[4]

Subjective effects


Physical effects

{{effects/visual| Visual effects are rarely experienced although sometimes they can occur as a result of sleep deprivation caused by the drug or as a result of the blood pressure lowering effect.


  • Double Vision

This effect is rare and usually only occurs during offset of a high dosage.


  • Distortions - this is extremely rare and can occur either as a result of sleep deprivation or hypotension, this effect is usually mild and may occur if the user stands up suddenly.


  • Anxiety supression - occasionally Thebaine may suppress anxiety which is likely due to the metabolite Oripavine.
  • Pain relief - Thebaine has a mild analgesic effect comparable to that of Tramadol though it mechanism is largely unknown.

Experience reports

There are currently 0 experience reports which describe the effects of this substance in our experience index.

Additional experience reports can be found here:

Toxicity and harm potential

Thebaine is very toxic and high doses produce symptoms similar to strychnine poisoning. It is strongly recommended that one use harm reduction practices when using this substance.

Lethal dosage

Tolerance and addiction potential

Thebaine is considered of low abuse potential due to its toxic effects on the body.

Dangerous interactions


This dangerous interactions section is a stub.

As such, it may contain incomplete or invalid information. You can help by expanding upon or correcting it.

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

Legal status

Thebaine is controlled under international law, is listed as a Class A drug under the Misuse of Drugs Act 1971 in the United Kingdom, is controlled as an analog of a Schedule II drug per the Analog Act in the United States, and is controlled with its derivatives and salts, as a Schedule I substance of the Controlled Drugs and Substances Act in Canada.[5] The 2013 US Drug Enforcement Administration (DEA) aggregate manufacturing quota for thebaine (ACSCN 9333) was unchanged from the previous year at 145 metric tons.

See also

Use of this compound is not recommended due to its negative effects and toxicity.

External links

(List along order below)