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Substance Breakdown 190px-Thebaine skeletal.svg.png Chemical Nomenclature Common names Thebaine, Opium Substitutive name Paramorphine Systematic name dehydromorphine 3,6-dimethyl ether. Class Membership Psychoactive class Opioid/Stimulant Chemical class Morphian Routes of Administration WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.

⇣ Oral Dosage Bioavailability x% - y% [1] Threshold 10 mg Light 15 - 30 mg Common 30 - 60 mg Strong 60 - 100 mg Heavy 100 mg + Duration Total x - y hours Onset 15 - 30 minutes Come up 10 - 20 minutes Peak 1 - 2 hours Offset 2 - 4 hours After effects 8 - 12 hours DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

History and culture

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Thebaine (paramorphine), also known as codeine methyl enol ether, is an opiate alkaloid naturally occurring in opium poppies.


thebaine is chemically similar to both morphine and codeine, but has stimulatory rather than depressant effects. At high doses, it causes convulsions similar to strychnine poisoning. The synthetic enantiomer (+)-thebaine does show analgesic effects apparently mediated through opioid receptors, unlike the inactive natural enantiomer (−)-thebaine.[3] While thebaine is not used therapeutically, it is the main alkaloid extracted from Papaver bracteatum (Iranian opium / Persian poppy) and can be converted industrially into a variety of compounds, including hydrocodone, hydromorphone, oxycodone, oxymorphone, nalbuphine, naloxone, naltrexone, buprenorphine and etorphine. Butorphanol can also be derived from thebaine.[4]

Subjective effects

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Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), a research literature based on anecdotal reports and the personal experiences of PsychonautWiki contributors. As a result, they should be regarded with a healthy degree of skepticism. It is worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become much more likely with higher doses and may include addiction, serious injury, or death. {{effects/base


Physical effects

{{effects/visual| Visual effects are rarely experienced although sometimes they can occur as a result of sleep deprivation caused by the drug or as a result of the blood pressure lowering effect.


  • Double Vision

This effect is rare and usually only occurs during offset of a high dosage.



  • Anxiety or Anxiety Suppression

Thebaine raises anxiety due to its CNS stimulant and excitetory activity, occasionally it may suppress anxiety which is likely due to the metabolite, oripavine.

Thebaine has a mild analgesic effect comparable to that of Dextropropoxyphene though it mechanism is largely unknown

Experience reports

There are currently 0 experience reports which describe the effects of this substance in our experience index.

Additional experience reports can be found here:

Toxicity and harm potential

Thebaine is very toxic and high doses produce symptoms similar to strychnine poisoning. It is strongly recommended that one use harm reduction practices when using this substance.

Lethal dosage

Tolerance and addiction potential

Thebaine is considered of low abuse potential due to its toxic effects on the body.

Dangerous interactions


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Although many psychoactive substances are reasonably safe to use on their own, they can suddenly become dangerous or even life-threatening when combined with other substances. The following list includes some known dangerous combinations (although it is not guaranteed to include all of them). Independent research (e.g. Google, DuckDuckGo) should always be conducted to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

Legal status

Thebaine is controlled under international law, is listed as a Class A drug under the Misuse of Drugs Act 1971 in the United Kingdom, is controlled as an analog of a Schedule II drug per the Analog Act in the United States, and is controlled with its derivatives and salts, as a Schedule I substance of the Controlled Drugs and Substances Act in Canada.[5] The 2013 US Drug Enforcement Administration (DEA) aggregate manufacturing quota for thebaine (ACSCN 9333) was unchanged from the previous year at 145 metric tons.

See also

Use of this compound is not recommended due to its negative effects and toxicity.

External links

(List along order below)


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