Substituted pyrrolidinophenones (or simply pyrrolidinophenones) are a chemical class of psychoactive compounds that are based on the structure of alpha-pyrrolidinopropiophenone (α-PPP). Pyrrolidinophenones have stimulant effects and are presumed to be more potent and addictive than others stimulants of class amphetamine and cathinone.
Presence of a pyrrolidine ring in any cathinone-like compound confers potent uptake blocking properties at DAT (dopamine transporter) and NET (norepinephrine transporter). Thus, pyrrolidinophenones are mechanistically distinct from ring-substituted cathinones, such as mephedrone and methylone, which act as non-selective substrates for monoamine transporters and trigger transmitter release. Importantly, MDPV and α-PVP are similar in potency and transporter selectivity, indicating that the presence of the 3,4-methylenedioxy substituent in MDPV does not exert much influence on the profile of transporter activity. By contrast, alkyl chain length extending from the α-carbon is a critical structural feature, with shorter chain length (i.e., α-PPP, methyl) yielding less potent transporter-blocking properties when compared to longer chain length (i.e., α-PVP, propyl).
List of substituted pyrrolidinophenones
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