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β-Endorphin (also known as beta-endorphin) is an endogenous opioid neuropeptide. Its name comprises of "endo" meaning endogenous and the opioid morphine. As a combination its name became endorphin as it is the endogenous ligand for the opioid receptors in the brain.



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β-Endorphin is a peptide of such amino acid sequence: Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys-Asn-Ala-Ile-Ile-Lys-Asn-Ala-Tyr-Lys-Lys-Gly-Glu.[1]


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β-Endorphin binds to μ-opioid and δ-opioid receptors with high affinity and to κ-opioid receptors at a lower affinity.[2]

Subjective Effects

beta-Endorphin has effects similar to that to morphine. subjective effects include euphoria, appetite suppression, temporary erectile dysfunction, mild stimulation that can be described as exhilaration combined with euphoria, increased libido, anxiety suppression and sedation, which normally makes the user feel relaxed and calm and causes improvement in sleep.

See also

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