LSA adducts

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LSA adducts
Chemical Nomenclature
Common names LSA, Ergine
Substitutive name d-Lysergic acid amide / d-Lysergamide
Systematic name (8β)-9,10-Didehydro-6-methyl-ergoline-8-carboxamide
Class Membership
Psychoactive class Psychedelic
Chemical class Lysergamide
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.

DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.


It has been documented that lysergic acid amide (LSA) is capable of forming adducts with various aldehydes.[1]

Lysergic acid hydroxyethylamide (LSH)

Lysergic acid hydroxyethylamide (LSH) is one example of such adducts, which is produced from LSA and acetaldehyde.

Due to the low boiling point of acetaldehyde (20.2 °C), LSH is very unstable and readily decomposes back into LSA and acetaldehyde. LSH and possibly other adducts are formed naturally in LSA containing plants, possibly explaining the differences in reported effects as fresh seeds may contain higher levels of LSH.

LSA is possibly not the main active principal of Ipomea seeds as commonly thought and appears instead to be a decomposition product of lysergic acid hydroxyethylamide (LSH). LSH is reported to have psychedelic properties vaguely similar to that of lysergic acid diethylamide (LSD). Animal tests have shown that LSH produces stimulant effects similar to LSD while LSA produces sedative effects. LSH is also said to produce less vasoconstriction than LSA, though this has yet to be scientifically confirmed.

Lysergic Acid Amide Acetaldehyde Lysergic Acid Hydroxyethylamide
LSA.svg Acetaldehyde.svg LSH.svg


Anecdotal reports indicate that LSH can be produced by mixing LSA and acetaldehyde in an acidic solution. It is also thought that LSA can form adducts with other aldehydes, some of which have been reported to be active although scientific evidence is lacking and nobody has ever been able to show any formation of LSH with an lab method. This is consistent with the very very low reactivity of amides like LSA.

Peppermint essential oil or fresh peppermint leaves have been used during extraction attempt to produce LSH and other adducts; however, the acetaldehyde content of most peppermint oil is very low. There are other aldehydes present in higher quantities, so if any adducts formed, they would not be LSH. Due to the low boiling point of acetaldehyde, an extraction must be carried out at a low temperature and the product is not easily stored. The process is notoriously difficult to achieve leading to many people refuting the adduct theory.


Cinnamylidene-bislysergamide, a theoretical adduct of two molecules of LSA and one of cinnamaldehyde, may be produced by introducing cinnamon bark essential oil to LSA. It appears to produce radically different subjective experiences to LSA with a rapid onset, rapid peak, and significantly shorter duration.

The 2:1 ratio is theorised based on similar cinnamaldehyde adducts such as cinnamylidene-bisacetamide and cinnamylidene-bisphenylacetamide, which are proven to form without the need for a catalyst.[citation needed]

Lysergic Acid Amide Cinnamaldehyde Cinnamylidene-bislysergamide
LSA.svg Cinnamaldehyde.svg Cinnamylidene-bislysergamide.svg

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