Fentanyl/Summary

This substance is extraordinarily potent (i.e. active in the microgram range). For this reason, it should be handled with extreme care and never be eyeballed. Fentanyl can also be fatal when combined with depressants such as opiates, benzodiazepines, barbiturates, gabapentinoids, thienodiazepines or other GABAergic substances.^[1]

It is strongly encouraged to wear gloves while handling, use volumetric dosing combined with a milligram scale, and to not consume either moderate or heavy dosages of other depressants in combination with this drug.

Main article: Fentanyl

Psychoactive class: Opioids

Chemical class: Anilidopiperidine, Substituted piperidines

Sublingual

Thresh Common Heavy

5 - 10 - 25 - 50 - 75 μg

Light Strong
- Total: 1 - 4 hours
- Onset: 15 - 30 minutes

Insufflated

Thresh Common Heavy

5 - 10 - 25 - 50 - 75 μg

Light Strong
- Total: 1 - 4 hours
- Onset: 15 - 30 minutes

Transdermal

Thresh Common Heavy

5 - 12 - 25 - 50 - 100 μg

Light Strong
- Total: 48 - 72 hours
- Onset: 2 - 4 hours

Harm potential

- Extremely addictive with a high potential for abuse
- Potentially fatal at heavy dosages, potentially lethal when mixed with depressants like alcohol or benzodiazepines, unintentionally transporting the substance from the skin by touching the mouth, nose or eyes is dangerous

Tolerance

- Full tolerance is reached develops with prolonged and repeated use
- Decreases to half after 3 - 7 days
- Returns to baseline after 1 - 2 weeks
- Cross-tolerance with all other opioids