Talk:Estradiol

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Summary sheet: Estradiol
Estradiol
Estradiol.svg
Chemical Nomenclature
Common names Estradiol, Oestradiol, E2
Substitutive name Estra-1,3,5(10)-triene-3,17β-diol
Systematic name (1S,3aS,3bR,9bS,11aS)-11a-Methyl-2,3,3a,3b,4,5,9b,10,11,11a-decahydro-1H-cyclopenta[a]phenanthrene-1,7-diol
Class Membership
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



Oral
Dosage
Bioavailability 5%[2]
Light 1 - 2 mg[1]
Common 2 - 4 mg[1]
Strong 4 - 8 mg[1]
Heavy 12 mg +[1]
Duration









DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Interactions


Estradiol (also known as oestradiol, E or E2) is an estrogen steroid hormone and the major female sex hormone.

History and culture

It is a basic, natural estrogen. Chemically, it is a steroid, a derivative of estrone.

Responsible for the development of the female reproductive organs, proliferation of the endometrium, regulates the sexual cycle and affects sexual behavior. During the follicular phase, it is produced mainly in the ovaries by growing Graaf follicles. In the corpus luteum phase, it is secreted in very small amounts by the corpus luteum. It is also produced in the adrenal cortex and during pregnancy in the placenta.

Chemistry

Esters

As a medication estradiol is commonly(especially when injected) administered in the form of prodrug esters to improve duration of action.

Compound Halflife via IM Structure
Estradiol Valerate 1.2–7.2 days Estradiol valerate.svg
Estradiol Cypionate 8–10 days Estradiol cypionate.svg
Estradiol Enantate 5.6–7.5 days Estradiol enantate.svg
Estradiol Undecylate ~1 month Estradiol undecylate.svg

Pharmacology

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You can help by adding to it.

Subjective effects

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects
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Cognitive effects
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Experience reports

There are currently 0 experience reports which describe the effects of this substance in our experience index.

Additional experience reports can be found here:

Legal status

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This legality section is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

See also

External links

References