Piperine, along with its isomer chavicine, is the alkaloid responsible for the pungency of black pepper and long pepper. Piperine is commercially available as an extract from black pepper using dichloromethane. Piperine is believed to increase the bioavaliability of a wide range of substances, hypothetically increasing their potency at the cost of duration.
Piperine can be supplemented in the dosage range of 2-5mg for the purpose of potentiating a desired drug's effect.
It should not to be confused with piperidine
In the body, it has been found to inhibit human CYP3A4 and P-glycoprotein, enzymes important for the metabolism and transport of xenobiotics and metabolites. In animal studies, piperine also inhibited other CYP 450 enzymes important for drug metabolism.