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Potentiators are a class of substance that can be used to enhance a users sensitivity to another substance, although they are also known to potentially cause effects on their own by interacting with endogenously produced substances. A well known example of the use of potentiators in psychonautics is the inclusion of Harmala alkaloids in Ayahuasca - a shamanic beverage introduced to modern culture through the indigenous peoples of Amazonian Peru. Since then potentiators have begun to emerge as a novel tool when used in conjunction with certain psychoactives, and as such many new combinations have sprung up in recent years.