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Chemophobia (or chemphobia or chemonoia) is an aversion to or prejudice against chemicals or chemistry. The phenomenon has been ascribed both to a reasonable concern over the potential adverse effects of synthetic chemicals, and to an irrational fear of these substances because of misconceptions about their potential for harm. People marketing products react to widespread chemophobia with products marketed with an appeal to nature.

Chemophobic drug users might view cannabis as harmless but synthetic drugs like 2C-B as dangerous (even if it would be sold as an approved pharmaceutical medicine).

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