Rhodocollybia maculata

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Rhodocollybia maculata
Taxonomical nomenclature
Kingdom Fungi
Phylum Basidiomycota
Class Agaricomycetes
Order Agaricales
Family Marasmiaceae
Genus Rhodocollybia
Species R. maculata
Common nomenclature
Common names Spotted Toughshank
Mycological Characteristics
Active constituents Collybolide, various analogs of the former

Rhodocollybia maculata, common name Spotted Toughshank, is a species of fungus in the mushroom family Marasmiaceae. One of its chemical constituents, collybolide, is a highly potent and selective K-opioid receptor agonist like Salvinorin A. However, unlike salvinorin A it exhibits biased k-opioid agonist activity.

Along with an easily modifiable structure compared with salvinorin A, collybolide is an ideal candidate for the development of novel therapeutics with reduced side effects targeting the K-opioid receptor. It is unknown if collybolide is a hallucinogen in humans.[1] The Rhodocollybia maculata mushroom is considered inedible because of its toughness and bitter flavor.

Structure of naturally occurring analogs from Rhadocollybia maculata side-by-side to Salvinorin A[2] .

External links


  1. Gupta, Achla; Gomes, Ivone; Bobeck, Erin N.; Fakira, Amanda K.; Massaro, Nicholas P.; Sharma, Indrajeet; Cavé, Adrien; Hamm, Heidi E.; Parello, Joseph; Devi, Lakshmi A. (2016). "Collybolide is a novel biased agonist of κ-opioid receptors with potent antipruritic activity". Proceedings of the National Academy of Sciences. 113 (21): 6041–6046. doi:10.1073/pnas.1521825113. ISSN 0027-8424. PMC 4889365Freely accessible. 
  2. Chakraborty, Soumen; Majumdar, Susruta (2020). "Natural Products for the Treatment of Pain: Chemistry and Pharmacology of Salvinorin A, Mitragynine, and Collybolide". Biochemistry. doi:10.1021/acs.biochem.0c00629. ISSN 0006-2960.