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|Common names||Spotted Toughshank|
|Active constituents||Collybolide, various analogs of the former|
Rhodocollybia maculata, common name Spotted Toughshank, is a species of fungus in the mushroom family Marasmiaceae. One of its chemical constituents, collybolide, is a highly potent and selective K-opioid receptor agonist like Salvinorin A. However, unlike salvinorin A it exhibits biased k-opioid agonist activity.
Along with an easily modifiable structure compared with salvinorin A, collybolide is an ideal candidate for the development of novel therapeutics with reduced side effects targeting the K-opioid receptor. It is unknown if collybolide is a hallucinogen in humans. The Rhodocollybia maculata mushroom is considered inedible because of its toughness and bitter flavor.
- Taxonomy and morphology of Rhodocollybia maculata (mushroomexpert.com)
- Rhodocollybia maculata (Wikipedia)
- Gupta, Achla; Gomes, Ivone; Bobeck, Erin N.; Fakira, Amanda K.; Massaro, Nicholas P.; Sharma, Indrajeet; Cavé, Adrien; Hamm, Heidi E.; Parello, Joseph; Devi, Lakshmi A. (2016). "Collybolide is a novel biased agonist of κ-opioid receptors with potent antipruritic activity". Proceedings of the National Academy of Sciences. 113 (21): 6041–6046. doi:10.1073/pnas.1521825113. ISSN 0027-8424. PMC .
- Chakraborty, Soumen; Majumdar, Susruta (2020). "Natural Products for the Treatment of Pain: Chemistry and Pharmacology of Salvinorin A, Mitragynine, and Collybolide". Biochemistry. doi:10.1021/acs.biochem.0c00629. ISSN 0006-2960.