Psilocybin mushroom lemon tek

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Theoretical modes of action

Dephosphorylation

Psilocybin is a prodrug to psilocin, which is primarily responsible for the psychoactive effects of psilocybin mushrooms. The conversion process, known as dephosphorylation, begins upon entering the stomach. This is one of the reasons why psilocybin mushrooms take about an hour before their effects begin.

The lemon tek theory suggests the acid in the lemon juice jump starts the conversion of psilocybin into psilocin. There are two processes by which psilocybin can be dephosphorylated [1] into psilocin- either via the alkaline phosphatase enzyme in the intestine and kidney, or in acidic environments like the stomach.[2] In theory, lemon juice, which has a pH of around 2, should be acidic enough to dephosphorylate psilocybin in the same way the stomach can (with a pH of 1.5 to 3.5 in humans).[3] Purported effects include faster onset, a more intense trip, and reduced nausea.

Increased absorption

Factors that contribute to improved absorption:

  1. The mushroom are ground up.
  2. The mushroom are soaked in water.
  3. Acids extract the alkaloids into the solution, that are absorbed quicker in your stomach than your stomach having to break down fungus material to get the actives out.

Materials

  • Psilocybin mushrooms
  • Small glass
  • Fresh lemon juice
  • Water

Procedure

  1. Grind your mushrooms or truffles into a very fine powder
  2. Place this powder into the glass
  3. Fill the glass with just enough lemon juice to cover the powder
  4. Leave for 20 minutes, and stir every 5. Do not leave for longer than 20 minutes
  5. Fill the glass with some water, swirl, making sure to get all bits of the mushroom, and drink

References

  1. Hallucinogenic mushrooms drug profile - http://www.emcdda.europa.eu/publications/drug-profiles/mushrooms
  2. Ricardo Jorge Dinis-Oliveira (2017) Metabolism of psilocybin and psilocin: clinical and forensic toxicological relevance, Drug Metabolism Reviews, 49:1, 84-91,
  3. Marieb EN, Hoehn K (2010). Human anatomy & physiology. San Francisco: Benjamin Cummings. ISBN 0-8053-9591-1.