Template:Warning/Nicotine

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The nicotine metabolite N-nitrosonornicotine is classified as a IARC Group 1 carcinogen

Nicotine in the mouth and stomach can react to form N-nitrosonornicotine (NNN),[1] a known type 1 carcinogen,[2] suggesting that consumption of non-tobacco forms of nicotine may still play a role in carcinogenesis.[3] This suggests that even oral nicotine replacement therapy products could theoretically contribute to cancer risk.

To stay safer: Nicotine patches used as directed do not pose this risk, since NNN formation does not occur through absorption via the skin.

  1. ↑ Knezevich A, Muzic J, Hatsukami DK, Hecht SS, Stepanov I (February 2013). "Nornicotine nitrosation in saliva and its relation to endogenous synthesis of N'-nitrosonornicotine in humans". Nicotine & Tobacco Research. 15 (2): 591–5. doi:10.1093/ntr/nts172. PMC 3611998 Freely accessible. PMID 22923602. 
  2. ↑ "List of Classifications – IARC Monographs on the Identification of Carcinogenic Hazards to Humans". monographs.iarc.fr. Retrieved 2020-07-22. 
  3. ↑ Sanner T, Grimsrud TK (2015-08-31). "Nicotine: Carcinogenicity and Effects on Response to Cancer Treatment - A Review". Frontiers in Oncology. 5: 196. doi:10.3389/fonc.2015.00196 Freely accessible. PMC 4553893 Freely accessible. PMID 26380225. 
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