"In addition, LSD-induced RSFC [Resting State Functional Connectivity] between the thalamus and right fusiform gyrus and insula correlated with subjective visual and auditory alterations, respectively (Mueller et al, 2017b). Remaining to be determined is the way in which LSD-induced increases in thalamocortical connectivity may be linked to the thalamic gating of perceptions (Mueller et al, 2017b). In contrast to the higher connectivity between neural networks while under the effects of LSD, LSD globally decreased within-network RSFC (integrity) and within-network signal variance (Carhart-Harris et al, 2016c) (Figure 2a).
(a) Mean percentage differences (+SEM) in CBF (red), integrity (blue), and signal variance (green) in 12 different resting-state networks (RSNs) under LSD relative to placebo (red asterisks indicate statistical significance, *P<0.05; **P<0.01, Bonferroni corrected). (b) Differences in between-RSN RSFC or RSN ‘segregation’ under LSD vs placebo. Each square in the matrix represents the strength of functional connectivity (positive=red, negative=blue) between a pair of different RSNs (parameter estimate values). The matrix on the far right displays the between-condition differences in covariance (t values): red=reduced segregation and blue=increased segregation under LSD. White asterisks represent significant differences (P<0.05, FDR corrected; n=15). Reproduced from Carhart-Harris et al (2016c)."
- Liechti, M. E. (2017). Modern clinical research on LSD. Neuropsychopharmacology, 42(11), 2114. https://doi.org/10.1038/npp.2017.86