Talk:Pipamperone
Pipamperone:
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- Pipamperone
- Summary
Pipamperone (INN, USAN, BAN), is a typical antipsychotic of the butyrophenone class, primarily used to treat psychotic disorders like schizophrenia. It was discovered at Janssen Pharmaceutica in 1961. This medication is not approved for use in the United States, but it is commonly used in Europe.
- Pharmacology
- Pharmacodynamics
Pipamperone acts as an antagonist of the 5-HT2A, 5-HT2B, 5-HT2C, D2, D3, D4, α1-adrenergic, and α2-adrenergic receptors. It is also a partial agonist of the 5-HT1A receptor. Its antagonistic activity at the D2 receptor is believed to confer antipsychotic properties, while its 5-HT2A receptor antagonist activity is thought to reduce side effects and augment its efficacy against the positive symptoms of schizophrenia.
- Pharmacokinetics
As for pharmacokinetics, detailed information is still somewhat limited. Pipamperone is known to be well absorbed from the gastrointestinal tract and to undergo first-pass metabolism. It is also known to be highly protein-bound in plasma.
- Medical Uses
Pipamperone is primarily used to treat various forms of psychosis, including schizophrenia and acute psychosis. It can also be used in lower doses as a mood stabilizer for those diagnosed with bipolar disorder. Additionally, it's sometimes used off-label for managing behavioral problems in patients with dementia.
- Side Effects
Common side effects of Pipamperone include drowsiness, extrapyramidal side effects, hyperprolactinaemia, and weight gain. However, compared to other typical antipsychotics, it is less likely to induce extrapyramidal side effects.
- Contraindications
Pipamperone should not be used in individuals with known hypersensitivity to the drug, severe CNS depression, or comatose states. Furthermore, its use is contraindicated in patients with pheochromocytoma, circulatory collapse, or subcortical brain damage.
- Drug Interactions
Pipamperone may increase the central nervous system depressant (CNS depressant) activities of other medications. This can increase the risk of side effects such as drowsiness, dizziness, and difficulty concentrating. Some individuals, particularly the elderly, may also experience impairment in thinking, judgment, and motor coordination.
- Legal Status
Pipamperone is not approved for use in the United States but is available in certain European countries. The legal status varies by country, and users are advised to check the status in their specific location before use.
- Research
As of the current update in 2023, further research is needed to fully understand the long-term effects and potential uses of Pipamperone.
- See Also
1. Antipsychotics 2. Butyrophenones 3. Schizophrenia
--- The information provided here is based on current knowledge and should be used for educational purposes only. It does not substitute for professional medical advice. Please consult with a healthcare provider before starting or changing any medications.
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