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Naphazoline, is a vasoconstrictor and decongestant. Naphazoline has marked alpha adrenergic activity.


Ophthalmic drug administration

Eye drops (brand names Clear Eyes, and Cleari) narrowing swollen blood vessels (ophthalmic arteries, and ophthalmic veins) to relieve red eye.[1]

Marijuana induces corneal vasodilation (so called red eye) and a reduction of intraocular pressure (IOP).[2]

Dangerous interactions

  • MAOIs - due to its alpha adrenergic activity.


  1. Hosten LO, Snyder C (2020). "Over-the-Counter Ocular Decongestants in the United States - Mechanisms of Action and Clinical Utility for Management of Ocular Redness". Clinical Optometry. 12: 95–105. doi:10.2147/OPTO.S259398. PMC 7399465Freely accessible. PMID 32801982. 
  2. Yazulla, S (September 2008). "Endocannabinoids in the retina: from marijuana to neuroprotection". Progress in retinal and eye research. 27 (5): 501–26. doi:10.1016/j.preteyeres.2008.07.002. PMID 18725316.