Talk:Fluetizolam
Fatal overdose may occur when thienodiazepines are combined with other depressants such as opiates, benzodiazepines, barbiturates, gabapentinoids, alcohol or other GABAergic substances.[1]
It is strongly discouraged to combine these substances, particularly in common to heavy doses.
Fluetizolam (also known as 2'-Fluorodeschloroetizolam or FluEtiz) is a designer drug in the thienodiazepine family of drugs. It’s closely related to drugs like diazepam (Valium), alprazolam (Xanax), and clonazolam (Klonopin). It was patented in Japan by Yoshitomi Pharmaceutical in the 90s but never made it to market. It’s been “rediscovered” as a designer drug and is revered for being a particularly potent alternative to etizolam. The threshold dose for this substance is well below 1 mg. It’s used for managing anxiety, insomnia, and side effects of other drugs. Some users take it for its inebriating effects, which resemble the effects of alcohol or GHB.
Metabolism
Fluetizolam is extensively metabolized into an active metabolite α-hydroxyetizolam by the process of hydroxylation. The active metabolite also has an action similar to that of fluetizolam. CYP3A4 is the major cytochrome enzyme responsible for metabolism. The inactive metabolites are removed from the body through urine and feces, with the drug’s half-life ranging from 3 to 17 hours
Potency
Preliminary studies on this compound suggest it to be 6 to 10 times more potent than diazepam. And about 2 to 3 time as potent as Etizolam. This makes Fluetizolam a very potent benzo with a common dosage of 0.5–1.0 mg.
Duration
Total Duration: 5 - 7 hours
Onset: 15 - 30 minutes
Come up: 15 - 30 minutes
Peak: 2 - 3 hours
Offset: 1.5 - 2.5 hours
Oral Dosage
Threshold: 0.1 mg
Light: 0.25 - 0.5 mg
Common: 0.5 - 1 mg
Strong: 1 - 2 mg
Heavy: 2 mg +
IUPAC Name: (2-ethyl-4-(2-fluorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine