Talk:Flualprazolam

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Death may result when benzodiazepines are combined with other depressants such as opiates, barbiturates, gabapentinoids, thienodiazepines, alcohol or other GABAergic substances.[1]

It is strongly discouraged to combine these substances, particularly in common to heavy doses.

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This page has not been approved by the PsychonautWiki administrators.

It may contain incorrect information, particularly with respect to dosage, duration, subjective effects, toxicity and other risks.

Flualprazolam
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Chemical Nomenclature
Common names Flualprazolam
Substitutive name Flualprazolam
Systematic name 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-benzo[f] [1,2,4]triazolo[4,3-a] [1,4]diazepine
Class Membership
Psychoactive class Depressant
Chemical class Benzodiazepine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



Oral
Dosage
Threshold 50 - 100 µg
Light 0.1 - 0.3 mg
Common 0.3 - 0.5 mg
Strong 0.5 - 1 mg
Heavy 1+ mg
Duration
Total 5 - 8 hours
Onset 20 - 40 minutes
Peak 1 - 2 hours
Offset 2 - 6 hours
After effects 6 - 24 hours









DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.


Flualprazolam is a novel depressant substance of the benzodiazepine class. Flualprazolam is chemically related to alprazolam (Xanax), differing by the addition of a fluorine atom, and is reported to produce similar psychoactive effects.

Flualprazolam appears to have first become available for sale on the online research chemical market in 2017.[2]

Users should note that the sudden discontinuation of benzodiazepines can be dangerous or even life-threatening for individuals for heavy or long-term users. As a result, individuals who are physically dependent on this substance are advised to taper their dose by gradually lowering the amount taken each day over a prolonged period instead of stopping use abruptly.[3]

It is strongly advised to use harm reduction practices when using this substance.

History and culture

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Flualprazolam first appeared on the research chemical market around 2017[2]

Chemistry

Flualprazolam is a substance of the benzodiazepine class. Benzodiazepines contain a benzene ring fused to a diazepine ring, which is a seven membered ring with the two nitrogen constituents located at R1 and R4. The benzyl ring of flualprazolam is substituted at R8 with a chlorine group. Further, the diazepine ring is bonded at R5 to a phenyl ring. The only difference to alprazolam is a flourine group located at R2'. Flualprazolam also contains a 1-methylated triazole ring fused to and incorporating R1 and R2 of its diazepine ring. Flualprazolam belongs to a class of benzodiazepines containing this fused triazole ring, called triazolobenzodiazepines, distinguished by the suffix "-zolam".

Pharmacology

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Subjective effects

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Disclaimer: The effects listed below are cited from the Subjective Effect Index (SEI), which relies on assorted anecdotal reports and the personal experiences of PsychonautWiki contributors. As a result, they should be taken with a healthy amount of skepticism. It is worth noting that these effects will not necessarily occur in a consistent or reliable manner, although higher doses (common+) are more likely to induce the full spectrum of reported effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.

Physical effects
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Paradoxical effects
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Cognitive effects
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Experience reports

There are currently 0 experience reports which describe the effects of this substance in our experience index.

Additional experience reports can be found here:

Toxicity and harm potential

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We also recommend that you conduct independent research and use harm reduction practices when using this substance.

Flualprazolam likely has a low toxicity relative to dose. However, it is potentially lethal when mixed with depressants like alcohol or opioids.

It is strongly recommended that one use harm reduction practices when using this substance.

Lethal dosage

Dependence and abuse potential

Like most benzodiazepines, Flualprazolam is considered to be highly addictive with a high potential for abuse.

Tolerance will develop to the sedative-hypnotic effects within a couple of days of continuous use. After cessation, the tolerance returns to baseline in 7 - 14 days. However, in certain cases this may take significantly longer in a manner which is proportional to the duration and intensity of one's long-term usage.

Benzodiazepine discontinuation is notoriously difficult and potentially life-threatening for heavy or long-term users. There is an increased risk of seizure following discontinuation of benzodiazepines. Withdrawal symptoms or rebound symptoms may occur after ceasing usage abruptly following a few weeks or longer of steady dosing, and may necessitate a gradual dose reduction. Substances which lower the seizure threshold such as Tramadol should be avoided during withdrawal.

Dangerous interactions

Although many psychoactive substances are reasonably safe to use on their own, they can quickly become dangerous or even life-threatening when combined with other substances. The list below includes some known dangerous combinations (although it cannot be guaranteed to include all of them). Independent research (e.g. Google, DuckDuckGo) should always be conducted to ensure that a combination of two or more substances is safe to consume. Some interactions listed have been sourced from TripSit.

  • Stimulants - It can be dangerous to combine depressants with stimulants due to the risk of accidental excessive intoxication. Stimulants mask the sedative effect of depressants, which is the main factor most people use to gauge their level of intoxication. Once the stimulant effects wear off, the effects of the depressant will significantly increase, leading to intensified disinhibition, motor control loss, and dangerous black-out states. This combination can also potentially result in severe dehydration if one's fluid intake is not closely monitored. If choosing to combine these substances, one should strictly limit themselves to a pre-set schedule of dosing only a certain amount per hour until a maximum threshold has been reached.

Legal status

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Internationally, the WHO Expert Committee on Drug Dependence recommended in 2019 to place flualprazolam in Schedule 4 of the Convention on Psychotropic Substances of 1971.[4] This recommendation must be confirmed by the UN Commission on Narcotic Drugs in March 2020.

  • Germany: Flualprazolam is controlled under the NpSG (New Psychoactive Substances Act)[5] as of July 18, 2019.[6] Production and import with the aim to place it on the market, administration to another person and trading is punishable. Possession is illegal but not penalized.[7]
  • United Kingdom: Flualprazolam is controlled under the Psychoactive Substances Act.[citation needed]
  • United States: Flualprazolam currently remains unscheduled.[citation needed]

See also

External links

Literature

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References

  1. Risks of Combining Depressants (Tripsit) | https://tripsit.me/combining-depressants/
  2. 2.0 2.1 Flualprazolam - Google Trends | https://trends.google.com/trends/explore?date=all&geo=US&q=Flualprazolam
  3. Canadian Guideline for Safe and Effective Use of Opioids for Chronic Non-Cancer Pain - Appendix B-6: Benzodiazepine Tapering | http://nationalpaincentre.mcmaster.ca/opioid/cgop_b_app_b06.html
  4. Dr. Tedros Adhanom Ghebreyesus (November 15, 2019). "Letter of WHO Director-General to UN Secretary-General" (PDF). World Health Organization. Retrieved December 29, 2019. 
  5. "Anlage NpSG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019. 
  6. "Verordnung zur Änderung der Anlage des Neue-psychoaktive-Stoffe-Gesetzes und von Anlagen des Betäubungsmittelgesetzes" (PDF). Bundesgesetzblatt Jahrgang 2019 Teil I Nr. 27 (in German). Bundesanzeiger Verlag. July 17, 2019. Retrieved December 28, 2019. 
  7. "§ 4 NpSG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019. 

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