Allopregnanolone (also known as ALLO, AlloP, brexanolone, or Zulresso) is a naturally occurring neurosteroid which is made in the body from the hormone progesterone. As a medication, allopregnanolone is used to treat postpartum depression in adult women. It is given by injection into a vein.
Allopregnanolone acts as a positive allosteric modulator of the GABA-A receptor, the major biological target of the inhibitory neurotransmitter γ-aminobutyric acid (GABA). It has a wide variety of effects, including antidepressant, anxiolytic, stress-reducing, rewarding, prosocial, antiaggressive, prosexual, sedative, pro-sleep, cognitive, memory-impairment, analgesic, anesthetic, anticonvulsant, neuroprotective, and neurogenic effects.
| Allopregnanolone | | --- | | **Chemical Nomenclature** | | Common names | ALLO, AlloP, brexanolone, Zulresso | | Substitutive name | 5α-Pregnan-3α-ol-20-one | | Systematic name | 1-[(3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone | | **Class Membership** | | Psychoactive class | Neurosteroid | | Chemical class | Progestin | | **Routes of Administration** | | WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. | | ⇣ Intravenous | | Dosage | Threshold | 0.1 mg/kg | | Light | 0.1 - 0.2 mg/kg | | Common | 0.2 - 0.4 mg/kg | | Strong | 0.4 - 0.6 mg/kg | | Heavy | 0.6+ mg/kg | | Duration | Total | 6 - 12 hours | | Onset | 5 - 10 minutes | | Peak | 30 - 60 minutes | | Offset | 60 - 120 minutes | | After effects | 12 - 24 hours |
DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Allopregnanolone may interact with other substances that modulate the GABA-A receptor or affect neurosteroid synthesis or metabolism. These include:
- Benzodiazepines - Barbiturates - Opioids - Alcohol - Anticonvulsants - Antidepressants - Finasteride - Ketoconazole
It is strongly discouraged to combine these substances with allopregnanolone.
The effects of allopregnanolone are dose-dependent and may vary depending on the individual's sensitivity and tolerance.
- Physical effects
The physical effects of allopregnanolone may include:
- Sedation - Muscle relaxation - Dizziness - Nausea - Headache - Flushing - Dry mouth
- Cognitive effects
The cognitive effects of allopregnanolone may include:
- Anxiety suppression - Disinhibition - Empathy enhancement - Euphoria - Mood enhancement - Stress reduction - Cognitive impairment - Memory impairment - Amnesia
- After effects
The after effects of allopregnanolone may include:
- Residual sedation - Residual anxiety suppression - Residual mood enhancement - Residual cognitive impairment