Talk:Perspective distortion

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Neurological Analysis

Macropsia and micropsia may arise on the grounds of abnormal cortical processing[1][2][3] related to LSD induced damage at cortical levels.[1][4]

LSD intake might produce short-term limited and reversible damage of the lateral geniculate nucleus leading to dysfunction of the parvocellular cells which may modulate the perception of forms and shapes, namely, macropsia and micropsia, and magnocellulars cells which may modulate the perception of movement of still objects, namely, pelopsia and teleopsia.[1][2][3][4][5]


  1. 1.0 1.1 1.2 Lev-Ran, S. (2015). LSD-associated" Alice in Wonderland Syndrome"(AIWS): A Hallucinogen Persisting Perception Disorder (HPPD) Case Report. The Israel journal of psychiatry and related sciences, 52(1), 67-68.
  2. 2.0 2.1 Abe K, Oda N, Araki R, Igata M. Macropsia, micropsia, and episodic illusions in Japanese adolescents. J Am Acad Child Adolesc Psychiatry 1989; 28:493-496.
  3. 3.0 3.1 Schneck JM. Macropsia. Am J Psychiatry 1965; 121:1123-1124.
  4. 4.0 4.1 Lerner AG, Rudinski D, Bor O, Goodman C. Flashback and HPPD: A clinical-oriented concise review. Isr J Psychiatry Relat Sci 2014; 51:296-302.
  5. Lerner AG, Gelkopf M, Skladman I, Oyffe I, Finkel B, Sigal M, Weizman A. Flashback and hallucinogen persisting perception disorder: Clinical aspects and pharmacological treatment approach. Isr J Psychiatry Relat Sci 2002, 39: 92-99