|Summary sheet: MXiPr|
|Common names||MXiPR, MXiP|
|Routes of Administration|
MXiPr (also known as 3-MeO-2′-Oxo-PCiPr and 2-(Isopropylamino)-2-(3-methoxyphenyl)cyclohexanone) is a novel dissociative substance of the arylcyclohexylamine class that produces dissociative and hallucinogenic effects when administered. It is a structural analog of MXE.
MXiPr began to gain popularity in late 2020  and is sold on the online grey area research chemical market as a legal or more readily available to Ketamine or MXE. The initial batch reportedly smelled like pokemon cards, or plastic, and many people allege that it was impure. As the metabolism of precursors can have unpredicted effects, it is strongly recommended to purify this substance yourself. if you suspect that it may be impure and are still keen on taking this substance, at the very least ensure that it to goes through first-pass metabolism by taking it orally.
Anecdotal reports seem to suggest that this drug experiences at least two plateaus. The first plateau at doses around 5-20mg, giving a two hour long experience similar to nitrous oxide, and the second plateau at doses around 20-40+mg giving an experience similar to a K-Hole, with a significantly warmer or "dreamier" afterglow. Little is known if higher plateaus exist, and it is advisable not to push it with this substance as it is extremely under-researched, and can provide a body load after the afterglow wears off, or in lower doses it will give you a mild hangover for 1-2 days.
Very little data exists about the pharmacological properties, metabolism, and toxicity of MXiPr, and it has a very brief history of human usage. It is strongly recommended that one use harm reduction practices if using this substance.
History and culture
This History and culture section is a stub.
As a result, it may contain incomplete or wrong information. You can help by expanding it.
Very little is known about the pharmacology about this substance, however as an arylcyclohexamine it is reasonable to assume that it is an NMDA receptor antagonist. NMDA receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. Dissociatives close the NMDA receptors by blocking them. This disconnection of neurons leads to loss of feeling, difficulty moving, and eventually an almost identical equivalent of the famous “k-hole.”
All of which can most likely be avoided entirely by practicing harm reduction by keeping dosages low, usage infrequent, and avoiding combinations.
|This subjective effects section is a stub.|
As such, it is still in progress and may contain incomplete or wrong information.
You can help by expanding or correcting it.
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), a research literature based on anecdotal reports and the personal experiences of PsychonautWiki contributors. As a result, they should be regarded with a healthy degree of skepticism. It is worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become much more likely with higher doses and may include addiction, serious injury, or death.
- Spontaneous bodily sensations - The MXiPr "body high" can be described as a sharp, pleasurable tingling sensation which is location specific to the hands, feet, and head.
- Perception of bodily lightness - This creates the sensation that the body is floating and has become entirely weightless. This effect is strangely stimulating and encourages physical activities at low to moderate doses by making the body feel light and effortless to move.
- Motor control loss - A loss of gross and fine motor control alongside balance and coordination is prevalent within MXiPr and becomes especially strong at higher doses. This means that one should be sitting down before the onset (unless experienced) in the case of falling over and injuring oneself.
- Spatial disorientation
- Tactile suppression - This partially to entirely suppresses one's sense of touch, creating feelings of numbness within the extremities. It is responsible for the anesthetic properties of this substance.
- Pain relief
- Physical autonomy
- Dizziness - Although uncommon, some people report dizziness under the influence of MXiPr, especially when used in combination with other substances.
- Nausea - High dose MXiPr experience can sometimes result in nausea and vomiting at the peak of the trip. For most people, this is surprisingly not as unpleasant as they would initially expect due to the accompanying detachment from the physical senses.
- Optical sliding
- Orgasm suppression - Orgasm enhancement can also be present, even at higher doses.
- Abnormal heartbeat
- Increased blood pressure - This effect is typically present at the higher doses.
- Increased heart rate - This effect has been reported as being more pronounced than other dissociatives, such as DCK or diphenidine.
- Increased perspiration
- Seizure - The extent to which this effect can be produced is unknown, but it appears the likelihood of this is more pronounced than other dissociatives, and can probably be avoided by keeping dosage within reasonable levels. The likelihood is also probably increased in those predisposed to them, especially while in physically taxing conditions such as being dehydrated, fatigued or undernourished.
- Visual acuity enhancement or Visual acuity suppression - While lower doses of this compound tend to produce mild visual acuity enhancements, this effect quickly disappears as one's general visual faculties become suppressed as the dose is increased.
- Double vision
- Frame rate suppression
- Pattern recognition suppression
- Internal hallucination (settings, sceneries, and landscapes; perspective hallucinations and scenarios and plots)
- Internal hallucination (autonomous entities; settings, sceneries, and landscapes; perspective hallucinations and scenarios and plots) - This effect can be comprehensively described through its variations as delirious in believability, fixed in style, equal in new experiences and memory replays in content, autonomous in controllability and solid in style.
- Anxiety suppression
- Cognitive euphoria
- Conceptual thinking
- Creativity enhancement
- Déjà vu
- Mania - Some users have reported mania on this drug. The frequency of which is undetermined. It is strongly recommended to use harm-reduction practices and not use this drug in high amounts or frequently. Most likely, it is more common than most arylcyclohexylamines but less common in occurrence compared to drugs like 3-MeO-PCP.
- Depersonalization & Derealization
- Delusion - Most likely, it is more common than most arylcyclohexylamines but less common in occurrence compared to drugs like 3-MeO-PCP.
- Dream potentiation
- Memory suppression
- Immersion enhancement
- Increased music appreciation
- Time distortion
- Thought deceleration
- Increased libido - This is reported to be present at lower dosage ranges.
The auditory effects found with MXiPr, although simplistic, are widely known to be particularly intense and consistent in their manifestation when compared to other hallucinogens. These effects include:
- Distortions - These distortions are very powerful and loud enough in their volume to make the original sound completely unrecognizable. They include phasers, white noise, high pitch tones and notes, flanging, changes in pitch, echo effects, and stuttering. In particular, the frequency of the stuttering is proportionally related to the intensity of the effects, especially ego death which occurs when the stuttering becomes continuous.
- Suppression - This effect can be described as a muffling and quieting of externally sourced sound which results in it sounding more indistinct and distant than it would usually be.
- Synaesthesia - Synaesthesia is sometimes reported on ketamine, especially at higher doses. Some users have reported the experience of being able to "hear colors" or "see sounds" in the k-hole state. However, it is not clear if ketamine is capable of producing synaesthesia as a normal effect or if it is merely eliciting it in predisposed individuals. More research is needed to understand the etiology of this reported effect.
There are currently 0 experience reports which describe the effects of this substance in our experience index.
Additional experience reports can be found here:
- Erowid Experience Vaults: MXiPr
- Reddit: MXiPr consistently gives seizures at higher dosages administered IM
Toxicity and harm potential
This toxicity and harm potential section is a stub.
As such, it may contain incomplete or even dangerously wrong information. You can help by expanding or correcting it.
It is strongly recommended that one use harm reduction practices when using this substance.
The toxicity and long-term health effects of recreational MXiPr use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because MXiPr has very little history of human usage.
Tolerance and addiction potential
Urinary tract effects
Regarding its long-term health effects when used repeatedly and over excessive periods, MXiPr seems to exhibit almost identical bladder and urinary tract problems to those found within ketamine, but to a lesser extent. This is because MXiPr is far more potent than ketamine, so significantly less of drug needs to be consumed. Symptoms of ketamine-induced cystitis can become severe and can be described as:
- Urinary frequency - Urinary frequency is the need to empty the bladder every few minutes.
- Urinary urgency - This can be described as a sudden, compelling need to urinate.
- Urinary pressure - This is experienced as a constant sensation of fullness in the bladder that is unrelieved by urination.
- Pelvic and bladder pain - Pain can develop suddenly and severely, especially since the bladder fills with urine.
- Hematuria - Hematuria is visible blood in the urine.
- Incontinence - This is the leakage of urine.
All of these, however, can easily be avoided by simply not using MXiPr on a daily or even weekly basis and consciously limiting one's usage of the substance.
This dangerous interactions section is a stub.
As such, it may contain incomplete or invalid information. You can help by expanding upon or correcting it.
Although many psychoactive substances are reasonably safe to use on their own, they can suddenly become dangerous or even life-threatening when combined with other substances. The following list includes some known dangerous combinations (although it is not guaranteed to include all of them). Independent research (e.g. Google, DuckDuckGo) should always be conducted to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.
- Stimulants - Both stimulants and dissociatives carry the risk of adverse psychological reactions like anxiety, mania, delusions and psychosis and these risks are exacerbated when the two substances are combined.
- Depressants - Because both depress the respiratory system, this combination can result in an increased risk of suddenly falling unconscious, vomiting and choking to death from the resulting suffocation. If nausea or vomiting occurs, users should attempt to fall asleep in the recovery position or have a friend move them into it.
This legality section is a stub.
As such, it may contain incomplete or wrong information. You can help by expanding it.
- Responsible use
- Research chemical
There are no known scholarly literature about this substance. You can help by adding some.
Please be sure to use an APA formatted reference
Please see the citation formatting guide if you need assistance properly formatting citations.
- MXiPr - Explore - Google Trends | https://www.google.com/trends/explore?date=all&q=MXiPr
- Isomer Design | https://isomerdesign.com/PiHKAL/explore.php?domain=pk&id=14059