1P-ETH-LAD

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Summary sheet: 1P-ETH-LAD
1P-ETH-LAD
1P-ETH-LAD.svg
Chemical Nomenclature
Common names 1P-ETH-LAD
Substitutive name 1-propionyl-6-ethyl-6-nor-lysergic acid diethyamide
Systematic name (6aR,9R)-4-propionyl-N,N-diethyl-7-ethyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide
Class Membership
Psychoactive class Psychedelic
Chemical class Lysergamide
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



Oral
Dosage
Threshold 25 µg
Light 30 - 60 µg
Common 60 - 100 µg
Strong 100 - 200 µg
Heavy 200 µg +
Duration
Total 6 - 12 hours
Onset 30 - 90 minutes
Peak 2 - 4 hours
Offset 2 - 4 hours
After effects 6 - 24 hours









DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Interactions
Cannabis
Stimulants
Tramadol
Lithium


1-Propionyl-6-ethyl-6-nor-lysergic acid diethyamide (also known as 1P-ETH-LAD) is a semisynthetic psychedelic substance of the lysergamide chemical class. It is a designer drug analog and suspected prodrug to ETH-LAD, which shares a close structural relationship with LSD and 1P-LSD. Anecdotal reports suggest that this compound produces largely similar psychedelic effects comparable to ETH-LAD or AL-LAD.

Like its parent compound ETH-LAD, this compound has been reported to be moderately to significantly more potent than LSD itself. It has also been reported as being subtly different in effect to LSD and is often described as being more visual and synaesthetic, with a deeper, less emotionally-charged headspace analogous to that of psychedelics like 2C-E or DPT. It has also been reported to be more likely to induce undesirable effects like anxiety, thought loops in addition to pronounced nausea and other discomforting physical effects it displays relative to other lysergamides.

Very little data exists about the pharmacological properties, metabolism, and toxicity of 1P-ETH-LAD, and it has little history of human usage before January 2016.[1] It has recently become commonly marketed alongside other designer psychedelics such as 1P-LSD and ETH-LAD as a legal alternative to LSD and is commercially distributed through online research chemical vendors.

Chemistry

Generic structure of a lysergamide

1P-ETH-LAD, or 1-propionyl-6-ethyl-6-nor-lysergic acid diethylamide, is a semi-synthetic alkaloid of the lysergamide family. 1P-ETH-LAD is a structural analog of lysergic acid, with an N, N-diethylamide functional group bound to RN of the chemical structure. This core polycyclic structure is an ergoline derivative and has tryptamine and phenethylamine groups embedded within it.

1P-ETH-LAD's structure contains a bicyclic hexahydro indole fused to a bicyclic quinoline group (nor-lysergic acid). 1P-ETH-LAD does not contain a methyl group substituted at R6 of its nor-lysergic acid skeleton; the nor- prefix represents this. Instead, 1P-ETH-LAD is substituted at R6 with an ethyl group and at R1 with a propionyl group. At carbon 8 of the quinoline, an N, N-diethyl carboxamide is bound.

1P-ETH-LAD is a chiral compound with two stereocenters at R5 and R8. 1P-ETH-LAD, also called (+)-D-1P-ETH-LAD, has an absolute configuration of (5R, 8R). The three other stereoisomers of 1P-ETH-LAD have not been shown to possess psychoactive properties.[2]

Pharmacology

Further information: Serotonergic psychedelic

This compound likely acts as a 5-HT2A partial agonist. The psychedelic effects are believed to come from 1P-ETH-LAD's efficacy at the 5-HT2A receptors. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

1P-ETH-LAD shares many common traits with its parent compound LSD; it appears to be roughly equal in potency as well as similar in mechanism although the progression and duration of effects are compressed (while remaining qualitatively less intense and more manageable) due to suspected differences in how it is metabolized. Research has shown formation of ETH-LAD from 1P-ETH-LAD incubated in human serum, suggesting that it functions as a pro-drug.[3]

Subjective effects

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This subjective effects section is a stub.

As such, it is still in progress and may contain incomplete or wrong information.

You can help by expanding or correcting it.

In comparison to other psychedelics such as psilocybin mushrooms, LSA and ayahuasca, 1P-ETH-LAD is significantly more stimulating and fast-paced in its cognitive effects and general head space. In comparison to LSD, it is reported to be less anxiety-provoking and more emotionally comfortable and forgiving.

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects
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Visual effects
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Experience reports

Anecdotal reports which describe the effects of this compound within our experience index include:

Additional experience reports can be found here:

Toxicity and harm potential

The toxicity and long-term health effects of recreational 1P-ETH-LAD use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 1P-ETH-LAD is a research chemical with very little history of human usage.

Anecdotal reports from those who have tried 1P-ETH-LAD suggests that there are no negative health effects attributed to simply trying the substance by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed).

Independent research should always be conducted to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices when using this substance.

Tolerance and addiction potential

1P-ETH-LAD is not habit-forming and the desire to use it can actually decrease with use. Like with most psychedelics, it is thought to be most often self-regulating rather than self-reinforcing.

Tolerance to the effects of 1P-ETH-LAD is built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). It should be noted that this only applies to the physiological tolerance. Mental or psychological tolerance is thought by some to take two weeks or more for the full experience to re-manifest.

Due to its activity at the 5-HT2A receptor, 1P-ETH-LAD presents cross-tolerance with all psychedelics, meaning that after the consumption of 1P-ETH-LAD all psychedelics (particularly the tryptamines and other lysergamides) will display a reduced effect.

Dangerous interactions

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

Legal status

It is unclear in many countries whether this compound is legal or not and one should take precaution by assuming it is illegal to avoid legal issues.

  • Canada: 1P-ETH-LAD is controlled as Schedule III substance under the Precursor Control Regulations of the Controlled Drugs and Substances Act.[5]
  • Germany: 1P-ETH-LAD is controlled under the NpSG (New Psychoactive Substances Act)[6] as of July 18, 2019.[7] Production and import with the aim to place it on the market, administration to another person and trading is punishable. Possession is illegal but not penalized.[8]
  • Switzerland: 1P-ETH-LAD can be considered a controlled substance as a defined derivative of Lysergic Acid under Verzeichnis E point 263. It is legal when used for scientific or industrial use.[9]
  • Turkey: 1P-ETH-LAD is a classed as drug and is illegal to possess, produce, supply, or import.[10]
  • United States: 1P-ETH-LAD may be considered illegal in the U.S. under the Federal Analogue Act.[citation needed]
  • United Kingdom: It is illegal to produce, supply, or import this substance under the Psychoactive Substance Act, which came into effect on May 26, 2016.[11].

See also

External links

Discussion

References

  1. "1P-ETH-LAD (Google Trends)". Retrieved January 1, 2020. 
  2. Nichols, David E. (2017). "Chemistry and Structure–Activity Relationships of Psychedelics". In Halberstadt, Adam L.; Vollenweider, Franz X.; Nichols, David E. Behavioral Neurobiology of Psychedelic Drugs. pp. 1–43. doi:10.1007/7854_2017_475. ISBN 978-3-662-55878-2. 
  3. Brandt, S. D.; Kavanagh, P. V.; Westphal, F.; Elliott, S. P.; Wallach, J.; Stratford, A.; Nichols, D. E.; Halberstadt, A. L. (2017). "Return of the lysergamides. Part III: Analytical characterization of N6‐ethyl‐6‐norlysergic acid diethylamide (ETH‐LAD) and 1‐propionyl ETH‐LAD (1P–ETH‐LAD)". Drug Testing and Analysis. 9 (10): 1641–1649. doi:10.1002/dta.2196. ISSN 1942-7611. 
  4. Talaie, H.; Panahandeh, R.; Fayaznouri, M. R.; Asadi, Z.; Abdollahi, M. (2009). "Dose-independent occurrence of seizure with tramadol". Journal of Medical Toxicology. 5 (2): 63–67. doi:10.1007/BF03161089. ISSN 1556-9039. 
  5. "Precursor Control Regulations (SOR/2002-359) - SCHEDULE". Government of Canada. Retrieved January 1, 2020. 
  6. "Anlage NpSG" (in German). Bundesministerium der Justiz und für Verbraucherschutz [Federal Ministry of Justice and Consumer Protection]. Retrieved December 10, 2019. 
  7. "Verordnung zur Änderung der Anlage des Neue-psychoaktive-Stoffe-Gesetzes und von Anlagen des Betäubungsmittelgesetzes" (PDF). Bundesgesetzblatt Jahrgang 2019 Teil I Nr. 27 (in German). Bundesanzeiger Verlag. July 17, 2019. pp. 1083–1094. Retrieved January 1, 2020. 
  8. "§ 4 NpSG" (in German). Bundesministerium der Justiz und für Verbraucherschutz [Federal Ministry of Justice and Consumer Protection]. Retrieved December 10, 2019. 
  9. "Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien" (in German). Bundeskanzlei [Federal Chancellery of Switzerland]. Retrieved January 1, 2020. 
  10. "Cumhurbaşkanı Kararı: Karar Sayısı: 1335" (PDF). Resmî Gazete, Sayı: 30837 (in Turkish). Başbakanlık Mevzuatı Geliştirme ve Yayın Genel Müdürlüğü [General Directorate of Legislation Development and Publication] (published July 20, 2019). July 19, 2020. 
  11. "Psychoactive Substances Act 2016". UK Government. Retrieved January 1, 2020.