Talk:Chloral hydrate

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Summary sheet: Chloral hydrate
Chloral hydrate
Chloral hydrate.svg
Chemical Nomenclature
Substitutive name Trichloroacetaldehyde monohydrate
Systematic name 2,2,2-Trichloroethane-1,1-diol
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.

Threshold 200 mg
Light 200 - 300 mg
Common 300 - 500 mg
Strong 500 - 1000 mg
Heavy 1000 mg +
Total 4 - 8 hours
Onset 30 minutes
Peak 1 hour
Offset 3 - 6 hours
After effects 12 - 24 hours

DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Chloral hydrate, or 2,2,2-Trichloroethane-1,1-diol is a hypnotic with a relatively long history of human usage. It was originally used as a treatment of insomnia and as a general sedative, however, with the widespread use of barbiturates, it was largely replaced and now it is only prescribed for patients who react to benzodiazepines paradoxically (it is, however, unapproved[1]). In the 19th century, it was one of the most popular recreational substances used, but now, recreational use is rare.



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Chloral hydrate is an organic compound produced by the chlorination of ethanol under acidic conditons. It is a colorless solid with an aromatic odor and is solid at room tempature.


Chloral hydrate is not active alone; rather, it is a prodrug for 2,2,2-Trichloroethanol. 2,2,2-TCE works as a positive allosteric modulator of GABAA receptors, like benzodiazepines.

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. These effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances of inducing a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.

Physical effects

Cognitive effects

External links