Methoxphenidine
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Methoxphenidine
Methoxphenidine.png
Chemical Nomenclature
Common names Methoxphenidine, MXP
Substitutive name 2-MeO-Diphenidine
Systematic name (±)-1-[1-(2-methoxyphenyl)-2-phenylethyl]piperidine
Routes of Administration


Oral
Dosage
Presumes no tolerance
Threshold 0 - 50 mg
Light 50 - 100 mg
Common 100 - 150 mg
Strong 150 - 200 mg
Heavy 200 mg+
Duration
Total 6 - 8 hrs









Methoxphenidine (MXP) or 1-[1-(2-methoxyphenyl)-2-phenylethyl]piperidine is a hallucinogenic dissociative compound of the piperidine chemical class. It has similar effects to that of the arylcyclohexylamine and morphinan classes of dissociatives.

It induces a state referred to as "dissociative anesthesia" and is used as a recreational drug. Very little is known about this substance but it has recently become freely available through online research chemical vendors where it is being sold as a designer drug and marketed as a replacement for MXE despite many users reporting it as qualitatively different in its effects and closer to that of DXM. Its pharmacology in humans has not yet been studied in any formal context.

Most methods of administration are possible, though the preferred method seems to be plugging or oral. IM, IV, and nasal require the tiniest bit of citric and results in a less gradual come-up (2 - 5 minutes for prelim effects).

Chemistry

General formula of a piperdine molecule.

MXP is classed as a piperdine drug. The piperdine molecule in MXP is attached to a benzene group via two carbon atoms on one side and a methoxybenzene molecule attached to one carbon on the other side.

Pharmacology

MXP has antagonistic action on NMDA receptors[1], which leads to anaesthetic and dissociative effects. Although it has not been formally studied, the feelings of physical and emotional euphoria which many users report suggests that it may also have action as a dopamine and / or a serotonin reuptake inhibitor.

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely if ever occur all at once but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical effects

The subjective physical effects of MXP are most similar to that of DXM than any other commonly used dissociative. They can be broken down into eight components all of which progressively intensify proportional to dosage. These are described below and generally include:

  • Tactile disconnection - This results in typical states of progressive physical disconnection but is far more consciously controllable than that of other dissociatives. This allows one to choose how much of their body they are currently aware of and connected to simply by directing their focus towards it even throughout higher states of disconnection and out of body experiences.
  • Spontaneous tactile sensations - The MXP "body high" is a soft, pleasurable vibrating sensation which can be felt all over the body which progressively intensifies throughout the onset before dissipating once the peak has been reached.
  • Tactile suppression - This partially to entirely suppresses one's own sense of touch, creating feelings of numbness within the extremities. It is responsible for the anaesthetic properties of this substance.
  • Motor control loss - A loss of gross and fine motor control alongside of balance and coordination is prevalent within nitrous and becomes especially strong at higher dosages. This means that one should be sitting down before the onset unless they are experienced in case of falling over and injuring oneself.
  • Euphoria - This results in feelings of physical euphoria which range between mild pleasure to powerfully all-encompassing bliss.
  • Decreased bodily weight - This creates the sensation that the body is floating and has become entirely weightless. This effect is strangely stimulating and encourages physical activities at low to moderate dosages by making the body feel light and effortless to move.
  • Dizziness - Although uncommon, some people report dizziness under the influence of MXP.
  • Physical autonomy

Cognitive effects

The cognitive effects of MXP are often described as particularly clear headed in comparison to other dissociatives even at heavy dosages. It is far more controllable, less disorientating and confusing at dosages of equal subjective intensity to that of MXE, DXM and Ketamine. The cognitive effects of MXP can be broken down into 8 separate subcomponents which are listed and described below:

Visual effects

The visual effects of MXP are unique in comparison to other dissociatives as they do not include open eye visual suppression, geometry or distortions but remain very powerful at appropriate dosages. The present effects progressively intensify according to dosage and commonly include:

Auditory effects

The auditory effects of MXP are common in their occurrence but unlike other more commonly used dissociatives, they are unlikely to suppress or distort auditory input and exhibit a range of effects which exclusively includes:

Afterglow

The afterglow is a feeling that occurs within the 24 hours after the trip itself. It is long lasting and as equally enjoyable as the trip itself to many people. It can be be described in terms of its physical sensation as one of euphoria, rejuvenation, relaxation and a light bounciness. In terms of its mental thought processes however, it can be described as a complete loss of anxiety, feelings of contentedness and an extremely high appreciation for music which dissipates a day or so after the experience.

Toxicity and harm potential

Lethal Dosage

The toxicity and long term health effects of recreational MXP use does not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because MXP is a research chemical with very little history of human usage. Anecdotal evidence from people who have tried MXP within the community suggests that there are no negative health effects attributed to simply trying this drug at low to moderate doses or using it very sparingly (but nothing can be completely guaranteed).

Tolerance and Addiction Potential

There is a very strong tolerance build up with MXP which results in the need to consume increasingly large doses in order to achieve the same level of effects. This should reset to baseline after 1 - 2 weeks. There may well be some addictive potential but this is still unknown.

Tolerance may be mitigated via preparing the citrate salt by mixing the chemical with citric acid or lemon juice, which will aid in absorption and increase effects.

Legal issues

MXP is currently a legal grey area world wide and freely available through the use of online research chemical vendors. However, this does not guarantee anybody to be immune from legal prosecution should they be found in possession of this substance as it is likely to vary from country to country.

See also

References

  1. MXP Patent | http://worldwide.espacenet.com/publicationDetails/biblio?CC=EP&NR=0346791&KC=&FT=E&locale=en_EP