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Changa is usually made by blending together any combination of desired smokable herbs and pouring a solvent (like isopropyl alcohol) containing DMT and an MAOI over the chosen blend of herbs, letting the mixture dry completely and then smoking the final product. Although there are many varieties of changa, like ayahuasca, the key active ingredients are DMT and an MAOI. The inclusion of the MAOI has been reported to serve to extend the experience by 10-30+ minutes, slow it down and render it more coherent and less chaotic than the experience of freebasing DMT.
An alternate way to get the type of experience changa typically provides is to orally dose an MAOI-containing agent beforehand (either pharmaceutical or herbal) and then proceed to vaporize DMT as one normally would after the MAOI has fully taken effect (one can often break through on significantly lower dower doses this way).
The percentages of DMT and MAOI concentration in the mixture can vary. A typical mixture would be characterized by breakthrough experiences at a dosage of approximately "one full bong bowl" (with each breath held in for at least 20 full seconds). There have also been reports of breakthroughs occurring with changa that has been rolled into joints, though this is a far less reliable method of doing do.
A guide to properly preparing changa can be accessed here.
"Enhanced leaf" is a related term that is sometimes used to describe DMT-containing herb-mixtures that do not contain MAOIs. Common herbs that can be used for this purpose can range from passionflower to mint leaves.
Toxicity and harm potential
Although many psychoactive substances are safe to use on their own, they can quickly become dangerous or even life-threatening when combined with other substances. The following lists some known dangerous combinations, but may not include all of them. A combination that appears to be safe in low doses can still increase the risk of injury or death. Independent research should always be conducted to ensure that a combination of two or more substances is safe to consume. Some interactions listed have been sourced from Tripsit.
- Stimulants - The neurotoxic effects of drugs like MDMA may be increased when combined with a changa mixture.
- 25x-NBOMe - Both the NBOMe series and this compound induce powerful stimulation and their interaction may cause severe side effects. These can include thought loops, seizures, increased blood pressure, vasoconstriction, increased heart rate, and heart failure (in extreme cases).
- DXM - This combination may cause increased heart rate and panic attacks.
- MXE - Increased heart rate and blood pressure may occur.
- Tramadol - This combination can increase the risk of seizures.
Serotonin syndrome risk
Combinations with the following substances can cause dangerously high serotonin levels. Serotonin syndrome requires immediate medical attention and can be fatal if left untreated.
- MAOIs such as syrian rue, banisteriopsis caapi, 2C-T-7, αMT, phenelzine, selegiline, and moclobemide
- Serotonin releasers such as MDMA, 4-FA, methamphetamine, methylone and αMT
- Selective serotonin re-uptake inhibitors (SSRIs)
- Serotonin-norepinephrine reuptake inhibitors (SNRIs) such as tramadol and DXM
There is an increased risk of serotonin syndrome when changa (or more specifically, the MAOI component of it) is taken with many antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs).
- Gillman, P. K. (2005). Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity. British Journal of Anaesthesia, 95(4), 434-441. https://doi.org/10.1093/bja/aei210